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This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentatively linked to ultra low frequency oscillations within the DMN. The current study evaluates the specificity of DMN abnormalities to neuronal oscillations in the ultra low frequency range, and examines the regional specificity of these DMN aberrations in medicated and unmedicated adults with, and those without ADHD. An individually matched sample of adults with and without ADHD completed 6\u2010minute sessions of resting\u2010state magnetoencephalography (MEG). Participants with ADHD were known responders to stimulant medications and completed two sessions (predrug\/postdrug). MEG data were coregistered to the participant's MRI, corrected for head motion, fitted to a regional\u2010level source model, and subjected to spectral analyses to extract neuronal population activity in regions of the DMN. The unmedicated adults with ADHD exhibited broadband deficits in medial prefrontal cortices (MPFC), but not other DMN regions compared to adults without ADHD. Unmedicated patients also showed abnormal cross\u2010frequency coupling in the gamma range between the MPFC and posterior cingulate areas, and disturbed balance within the DMN as activity in posterior regions was stronger than frontal regions at beta and lower frequencies, which dissipated at higher \u03b3\u2010frequencies. Administration of pharmacotherapy significantly increased prefrontal alpha activity (8\u201314 Hz) in adults with ADHD, and decreased the cross\u2010frequency gamma coupling. These results indicate that neurophysiological aberrations in the DMN of patients with ADHD are not limited to ultra slow oscillations, and that they may be primarily attributable to abnormal broadband activity in the MPFC. Hum Brain Mapp, 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21459","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T12:25:32Z","timestamp":1321619132000},"page":"566-574","source":"Crossref","is-referenced-by-count":54,"title":["Broadband neurophysiological abnormalities in the medial prefrontal region of the default\u2010mode network in adults with ADHD"],"prefix":"10.1002","volume":"34","author":[{"given":"Tony W.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Franzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Heinrichs\u2010Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole L.","family":"Knott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Wetzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.025"},{"key":"e_1_2_7_3_1","first-page":"842","article-title":"Mental health in the United States: Prevalence of diagnosis and medication treatment for attention\u2010deficit\/hyperactivity disorder\u2014United States, 2003","volume":"54","author":"Center for Disease Control and Prevention","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800376105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000381"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170500471X"},{"key":"e_1_2_7_8_1","first-page":"507","article-title":"Frequency distribution of the values of the correlation coefficient in samples of an indefinitely large population","volume":"10","author":"Fisher RA","year":"1915","journal-title":"Biometrika"},{"key":"e_1_2_7_9_1","first-page":"3","article-title":"On the probable error of a coefficient of correlation deduced from a small sample","volume":"1","author":"Fisher RA","year":"1921","journal-title":"Metron"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929042568532"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0825-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.057"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BRAT.0000032857.55223.5d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.2517-6161.1953.tb00135.x","article-title":"New light on the correlation coefficient and its transforms","volume":"15","author":"Hotelling H","year":"1953","journal-title":"J R Stat Soc B"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704002892"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.716"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21058"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4004-09.2009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.11.022"},{"key":"e_1_2_7_23_1","unstructured":"National Institute of Mental Health (NIMH)(2010): The numbers count: Mental disorders in America. 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