{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:28:04Z","timestamp":1787948884271,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Placebo analgesia (PA) is one of the most studied placebo effects. Brain imaging studies published over the last decade, using either positron emission tomography (PET) or functional magnetic resonance imaging (fMRI), suggest that multiple brain regions may play a pivotal role in this process. However, there continues to be much debate as to which areas consistently contribute to placebo analgesia\u2010related networks. In the present study, we used activation likelihood estimation (ALE) meta\u2010analysis, a state\u2010of\u2010the\u2010art approach, to search for the cortical areas involved in PA in human experimental pain models. Nine fMRI studies and two PET studies investigating cerebral hemodynamic changes were included in the analysis. During expectation of analgesia, activated foci were found in the left anterior cingulate, right precentral, and lateral prefrontal cortex and in the left periaqueductal gray (PAG). During noxious stimulation, placebo\u2010related activations were detected in the anterior cingulate and medial and lateral prefrontal cortices, in the left inferior parietal lobule and postcentral gyrus, anterior insula, thalamus, hypothalamus, PAG, and pons; deactivations were found in the left mid\u2010 and posterior cingulate cortex, superior temporal and precentral gyri, in the left anterior and right posterior insula, in the claustrum and putamen, and in the right thalamus and caudate body. Our results suggest on one hand that the modulatory cortical networks involved in PA largely overlap those involved in the regulation of emotional processes, on the other that brain nociceptive networks are downregulated in parallel with behavioral analgesia. Hum Brain Mapp, 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.21471","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T03:42:37Z","timestamp":1322624557000},"page":"738-752","source":"Crossref","is-referenced-by-count":186,"title":["Activation likelihood estimation meta\u2010analysis of brain correlates of placebo analgesia in human experimental pain"],"prefix":"10.1002","volume":"34","author":[{"given":"Martina","family":"Amanzio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A.","family":"Porro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cauda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00484.1999"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1293"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00179-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3458-05.2005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.12.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.08.027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1173"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(99)00134-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00149-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00327-5"},{"key":"e_1_2_7_13_1","first-page":"215","volume-title":"Measuring the Mind: Speed, Control and Age","author":"Burgess PW","year":"2005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.025"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0125"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20718"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180142"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00220973.1996.9943802"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20125"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20249"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/026432900410775"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/20178"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3556-05.2006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2007.18.3-4.173"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408576102"},{"key":"e_1_2_7_27_1","volume-title":"Users' Manual for BrainMap GingerALE 2.0. Copyright 2003\u20132009","author":"Laird AR","year":"2009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20136"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92762-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.01.037"},{"key":"e_1_2_7_33_1","first-page":"815","article-title":"Neural bases of conditioned placebo analgesia","volume":"151","author":"*Lui F","year":"2010","journal-title":"Pain"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.10.012"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0308"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00145-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-73971-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0821-z"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892902760807212"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00628-4"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.05.023"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00467-5"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067176"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(03)00061-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1027\/1618-3169.51.4.270"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.08.001"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.055046"},{"key":"e_1_2_7_49_1","first-page":"1","article-title":"Voxel\u2010based meta\u2010analysis of regional white\u2010matter volume differences in autism spectrum disorder versus healthy controls","volume":"16","author":"Radua J","year":"2010","journal-title":"Psychol Med"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.011"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.039"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.028"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.34"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-0795-5"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.012"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1131"},{"key":"e_1_2_7_58_1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.1093065","article-title":"Placebo\u2010induced changes in FMRI in the anticipation and experience of pain","volume":"303","author":"*Wager TD","year":"2004","journal-title":"Science"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3420-10.2011"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.04.003"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350142"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04623.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04424.x"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.21471","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.21471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:47:03Z","timestamp":1697460423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.21471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,29]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/hbm.21471"],"URL":"https:\/\/doi.org\/10.1002\/hbm.21471","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,29]]}}}