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Increased AD risk has been associated with differences in functional magnetic resonance imaging (fMRI) activity during memory tasks, but most of these studies have focused on possession of apolipoprotein E allele 4 (<jats:italic>APOE<\/jats:italic>4), a risk factor, but not causative variant, of late\u2010onset AD. Evaluation of fMRI activity in presymptomatic FAD mutation carriers versus noncarriers provides insight into preclinical changes in those who will certainly develop AD in a prescribed period of time. Adults from FAD mutation\u2010carrying families (nine mutation carriers, eight noncarriers) underwent fMRI scanning while performing a memory task. We examined fMRI signal differences between carriers and noncarriers, and how signal related to fMRI task performance within mutation status group, controlling for relative age and education. Mutation noncarriers had greater retrieval period activity than carriers in several AD\u2010relevant regions, including the left hippocampus. Better performing noncarriers showed greater encoding period activity including in the parahippocampal gyrus. Poorer performing carriers showed greater retrieval period signal, including in the frontal and temporal lobes, suggesting underlying pathological processes. <jats:italic>Hum Brain Mapp 34:3308\u20133319, 2013<\/jats:italic>. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.22141","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T03:39:12Z","timestamp":1342669152000},"page":"3308-3319","source":"Crossref","is-referenced-by-count":13,"title":["Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Meredith N.","family":"Braskie","sequence":"first","affiliation":[{"name":"Mary S. 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