{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:15:28Z","timestamp":1769127328764,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>A hypoglossal\u2013facial transfer is a common surgical strategy for reanimating the face after persistent total hemifacial palsy. We were interested in how motor recovery is associated with cortical reorganization of lip and tongue representation in the primary sensorimotor cortex after the transfer. Therefore, we used functional magnetic resonance imaging (fMRI) in 13 patients who underwent a hypoglossal\u2013facial transfer after unilateral peripheral facial palsy. To identify primary motor and somatosensory tongue and lip representation sites, we measured repetitive tongue and lip movements during fMRI. Electromyography (EMG) of the perioral muscles during tongue and lip movements and standardized evaluation of lip elevation served as outcome parameters. We found an association of cortical representation sites in the pre\u2010 and postcentral gyrus (decreased distance of lip and tongue representation) with symmetry of recovered lip movements (lip elevation) and coactivation of the lip during voluntary tongue movements (EMG\u2010activity of the lip during tongue movements). Overall, our study shows that hypoglossal\u2013facial transfer resulted in an outcome\u2010dependent cortical reorganization with activation of the cortical tongue area for restituded movement of the lip. Hum Brain Mapp 35:638\u2013645, 2014. \u00a9 2012 Wiley\u2010Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.22206","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T11:22:03Z","timestamp":1352114523000},"page":"638-645","source":"Crossref","is-referenced-by-count":8,"title":["Outcome\u2010dependent coactivation of lip and tongue primary somatosensory representation following hypoglossal\u2013facial transfer after peripheral facial palsy"],"prefix":"10.1002","volume":"35","author":[{"given":"Philipp","family":"Rottler","sequence":"first","affiliation":[{"name":"Functional Imaging Department Institute of Diagnostic Radiology and Neuroradiology University of Greifswald Germany"},{"name":"Department of Neurosurgery University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry W.S.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lotze","sequence":"additional","affiliation":[{"name":"Functional Imaging Department Institute of Diagnostic Radiology and Neuroradiology University of Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21399"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2259"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.1.615"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199412000-00047"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00096.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/375482a0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7309"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.05.054"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BRAT.0000019184.63249.e8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300202"},{"key":"e_1_2_5_13_1","first-page":"203","article-title":"Cortical reorganization in Bell's palsy","volume":"29","author":"Klingner CM","year":"2011","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/9145"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0556"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200009110-00032"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-2457(02)00380-2"},{"key":"e_1_2_5_18_1","first-page":"97","article-title":"Combination of TMS and fMRI reveals a specific pattern of reorganization in M1 in patients after complete spinal cord injury","volume":"24","author":"Lotze M","year":"2006","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240408"},{"key":"e_1_2_5_20_1","first-page":"985","article-title":"Method for quantitatively evaluating the lateralization of linguistic function using functional MR imaging","volume":"22","author":"Nagata SI","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_21_1","first-page":"340","article-title":"Defining functional limitation, disability, and societal limitations in patients with facial paresis: Initial pilot questionnaire","volume":"17","author":"Neely JG","year":"1996","journal-title":"Am J Otol"},{"key":"e_1_2_5_22_1","first-page":"37","article-title":"Hypoglossal\u2010facial anastomosis. A report of 60 cases","volume":"42","author":"Pellat JL","year":"1997","journal-title":"Ann Chir Plast Esthet"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215510395634"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410511"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-18-08043.1999"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411301203"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229318"},{"key":"e_1_2_5_28_1","unstructured":"HJ Sneddon 1973 Williams & Wilkins Baltimore 267"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-6-25"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600710"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:36:14Z","timestamp":1696480574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,5]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/hbm.22206"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22206","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,5]]}}}