{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:24:24Z","timestamp":1787592264441,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Netherlands Organization for Scientific Research (NWO, VIDI)","award":["91786368"],"award-info":[{"award-number":["91786368"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations\u2014mostly in the blood oxygen level dependent (BOLD) signal\u2014across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting\u2010state\u2010network consistency (RSNC)\u2014representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)\u2014in a crossover placebo\u2010controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug\u2010by\u2010time, time, drug and physiological rates) and each of these metrics. The drug\u2010by\u2010time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive\/salience and the working memory networks. The post\u2010hoc voxel\u2010wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC\/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929\u2013942, 2014. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.22224","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T12:40:39Z","timestamp":1356525639000},"page":"929-942","source":"Crossref","is-referenced-by-count":23,"title":["Spatial heterogeneity of the relation between resting\u2010state connectivity and blood flow: An important consideration for pharmacological studies"],"prefix":"10.1002","volume":"35","author":[{"given":"Najmeh","family":"Khalili\u2010Mahani","sequence":"first","affiliation":[{"name":"Institute of Psychology Leiden University Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center (LUMC) Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC) Leiden University Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J.","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center (LUMC) Leiden The Netherlands"},{"name":"C. J. Gorter Center for High\u2010field MRI, LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"de Rooij","sequence":"additional","affiliation":[{"name":"Institute of Psychology Leiden University Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC) Leiden University Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Oxford Center for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Oxford University Oxford United Kingdom"},{"name":"MIRA Institute for Biomedical Technology and Technical Medicine University or Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center (LUMC) Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC) Leiden University Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"van Gerven","sequence":"additional","affiliation":[{"name":"Center for Human Drug Research (CHDR) Leiden The Netherlands"},{"name":"Department of Neurology LUMC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge A.R.B.","family":"Rombouts","sequence":"additional","affiliation":[{"name":"Institute of Psychology Leiden University Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center (LUMC) Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC) Leiden University Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,26]]},"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:53:18Z","timestamp":1696477998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/hbm.22224"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22224","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}