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The default mode network (DMN) is a set of remote, functionally connected cortical nodes less active during executive tasks than at rest and is implicated in Theory of Mind, episodic memory, and other self\u2010reflective processes. We show that children with ASD have reduced connectivity between DMN nodes and increased local connectivity within DMN nodes and the visual and motor resting\u2010state networks. We show that, like the trajectory of synaptogenesis, internodal DMN functional connectivity increased as a quadratic function of age in typically developing children, peaking between, 11 and 13 years. In children with ASD, these long\u2010distance connections fail to develop during adolescence. These findings support the \u201cdevelopmental disconnection model\u201d of ASD, provide a possible mechanistic explanation for the Theory\u2010of\u2010Mind hypothesis of ASD, and show that the window for effectively treating ASD could be wider than previously thought. <jats:italic>Hum Brain Mapp 35:1284\u20131296, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.22252","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T09:26:38Z","timestamp":1358501198000},"page":"1284-1296","source":"Crossref","is-referenced-by-count":255,"title":["Dysmaturation of the default mode network in autism"],"prefix":"10.1002","volume":"35","author":[{"given":"Stuart D.","family":"Washington","sequence":"first","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Children's National Medical Center, Northwest, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmit","family":"Brar","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Warburton","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice T.","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin R.","family":"Mease\u2010Ference","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Girton","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayichew","family":"Hailu","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juma","family":"Mbwana","sequence":"additional","affiliation":[{"name":"Center for Functional and Molecular Imaging, Georgetown University Medical Center, Washington, District of Columbia"},{"name":"Department of Neurology, Georgetown University Medical Center, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Children's National Medical Center, Northwest, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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