{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:17Z","timestamp":1791396917326,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Previous imaging studies that investigated morphometric group differences of subcortical regions outside the substantia nigra between non\u2010demented Parkinson's patients and controls either did not find any significant differences, or reported contradictory results. Here, we performed a comprehensive morphometric analysis of 20 cognitively normal, early\u2010stage PD patients and 19 matched control subjects. In addition to relatively standard analyses of whole\u2010brain grey matter volume and overall regional volumes, we examined subtle localized surface shape differences in striatal and limbic grey matter structures and tested their utility as a diagnostic marker. Voxel\u2010based morphometry and volumetric comparisons did not reveal significant group differences. Shape analysis, on the other hand, demonstrated significant between\u2010group shape differences for the right pallidum. Careful diffusion tractography analysis showed that the affected parts of the pallidum are connected subcortically with the subthalamic nucleus, the pedunculopontine nucleus, and the thalamus and cortically with the frontal lobe. Additionally, microstructural measurements along these pathways, but not along other pallidal connections, were significantly different between the two groups. Vertex\u2010wise linear discriminant analysis, however, revealed limited accuracy of pallidal shape for the discrimination between patients and controls. We conclude that localized disease\u2010related changes in the right pallidum in early Parkinson's disease, undetectable using standard voxel\u2010based morphometry or volumetry, are evident using sensitive shape analysis. However, the subtle nature of these changes makes it unlikely that shape analysis alone will be useful for early diagnosis. <jats:italic>Hum Brain Mapp 35:1681\u20131690, 2014<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/hbm.22282","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T11:33:55Z","timestamp":1373974435000},"page":"1681-1690","source":"Crossref","is-referenced-by-count":97,"title":["Comprehensive morphometry of subcortical grey matter structures in early\u2010stage Parkinson's disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Ricarda A.L.","family":"Menke","sequence":"first","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford United Kingdom"},{"name":"Department of Psychiatry Warneford Hospital University of Oxford Oxford United Kingdom"},{"name":"Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Szewczyk\u2010Krolikowski","sequence":"additional","affiliation":[{"name":"Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Jbabdi","sequence":"additional","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Talbot","sequence":"additional","affiliation":[{"name":"Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Mackay","sequence":"additional","affiliation":[{"name":"FMRIB Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford United Kingdom"},{"name":"Department of Psychiatry Warneford Hospital University of Oxford Oxford United Kingdom"},{"name":"Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Hu","sequence":"additional","affiliation":[{"name":"Oxford Parkinson's Disease Centre (OPDC) University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_2_7_3_1","volume-title":"Non\u2010linear registration, aka Spatial normalisation","author":"Anderson JLR","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22799"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688699845078"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10502"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh088"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23465"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01657.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1437"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.5.413"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21161"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90472-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.07.030"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0967-5868(95)90007-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008247"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0914-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22592"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2372"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.12.010"},{"key":"e_1_2_7_30_1","first-page":"309","article-title":"Imaging degeneration of the substantia nigra in Parkinson disease with inversion\u2010recovery MR imaging","volume":"28","author":"Minati L","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050921"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf259"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq212"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530350033015"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.135"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1040"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1524"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.018"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.281"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200201000-00005"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80024-9"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:10:20Z","timestamp":1696363820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,16]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/hbm.22282"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22282","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,16]]}}}