{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:09:20Z","timestamp":1791198560017,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T00:00:00Z","timestamp":1377302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Excellence Initiative of the German federal and state governments","award":["DFG ZUK32\/1"],"award-info":[{"award-number":["DFG ZUK32\/1"]}]},{"name":"IZKF Aachen (Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Using resting\u2010state fMRI (rs\u2010fMRI) we investigated the functional integrity of resting\u2010state networks (RSN) in HD. 17 HD and 19 matched control participants were examined at a 3 Tesla MR scanner. After controlling for structural degeneration by means of voxel\u2010based morphometry, task\u2010free rs\u2010fMRI data were analyzed using Independent Component Analysis (ICA) and a dual\u2010regression approach in the context of genetic and clinical parameters. Further, we evaluated HD\u2010related differences in interregional connectivity between networks. RSN analysis showed a significant increase in intrinsic functional connectivity in the HD sample compared with controls, including the thalamus, striatum, prefrontal, premotor, and parietal maps. A subset of the Default Mode Network (DMN) was also affected. In the HD cohort, motor impairment correlated with higher network connectivity in mainly motor and parietal cortices. Deteriorating total functional capacity was additionally associated with higher connectivity in the striatum, thalamus, insular and frontal areas. This pattern of increased activity in intrinsic functional networks might suggest a reduced ability of intra\u2010network differentiation with clinical disease progression in HD. Finally, results showed reduced long\u2010range connectivity between parietal ICA components in HD compared to controls, indicating impaired functional coupling between interregional networks in HD. Our data demonstrates that functional connectivity is profoundly altered in HD, both within and between RSN. Rs\u2010fMRI analysis may provide additional valuable insights into neuronal dysfunctions beyond HD\u2010related structural degeneration and disruptions of functional circuits in HD.\n                    <jats:italic>Hum Brain Mapp 35:2582\u20132593, 2014<\/jats:italic>\n                    . \u00a9\n                    <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/hbm.22351","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T08:58:39Z","timestamp":1377334719000},"page":"2582-2593","source":"Crossref","is-referenced-by-count":103,"title":["Altered resting\u2010state connectivity in Huntington's Disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Cornelius J.","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imis","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Institute of Neuroscience and Medicine, Research Center J\u00fclich, J\u00fclich  Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sa\u00df","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Department of Neurology Asklepios Hospital Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Mirzazade","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Institute of Neuroscience and Medicine, Research Center J\u00fclich, J\u00fclich  Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schiefer","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Jon","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Institute of Neuroscience and Medicine, Research Center J\u00fclich, J\u00fclich  Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University Aachen Germany"},{"name":"Institute of Neuroscience and Medicine, Research Center J\u00fclich, J\u00fclich  Germany"},{"name":"JARA BRAIN \u2013 Translational Brain Medicine J\u00fclich and Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.10.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1075"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn223"},{"key":"e_1_2_6_9_1","unstructured":"DoganI EickhoffSB SchulzJB ShahNJ LairdAR FoxPT ReetzK(2012):Consistent neurodegeneration and its association with clinical progression in Huntington's disease: A coordinate\u2010based meta\u2010analysis Neurodegener Dis:DOI: 339528. Epub ahead of print."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm217"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811879106"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_6_14_1","first-page":"19","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox MD","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.08.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328306f2c5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110204"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh185"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01769-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2251011301"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410521"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.041"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh608"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.063"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.1.1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70170-X"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70276-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70263-0"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827689d6"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.098368"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.095"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0306-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.60"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.06.014"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.198"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.004"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.080"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:32:45Z","timestamp":1696383165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,24]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/hbm.22351"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22351","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,24]]}}}