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Clinically, they are associated with the fragile X\u2010Associated Tremor\/Ataxia Syndrome, a late\u2010onset neurodegenerative disorder with diffuse white matter neuropathology. Here, we conducted first\u2010ever graph theoretical network analyses in fXPCs using 30\u2010direction diffusion\u2010weighted magnetic resonance images acquired from 42 healthy controls aged 18\u201344 years (HC; 22 male and 20 female) and 46 fXPCs (16 male and 30 female). Globally, we found no differences between the fXPCs and HCs within each gender for all global graph theoretical measures. In male fXPCs, global efficiency was significantly negatively associated with the number of CGG repeats. For nodal measures, significant group differences were found between male fXPCs and male HCs in the right fusiform and the right ventral diencephalon (for nodal efficiency), and in the left hippocampus [for nodal clustering coefficient (CC)]. In female fXPCs, CC in the left superior parietal cortex correlated with counting performance in an enumeration task. <jats:italic>Hum Brain Mapp 35:4518\u20134530, 2014<\/jats:italic>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.22491","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T12:53:43Z","timestamp":1393505623000},"page":"4518-4530","source":"Crossref","is-referenced-by-count":15,"title":["Altered structural brain connectome in young adult fragile X premutation carriers"],"prefix":"10.1002","volume":"35","author":[{"given":"Alex","family":"Leow","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Bioengineering University of Illinois at Chicago Chicago, Illinois, and Community Psychiatry, Sacramento California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Harvey","sequence":"additional","affiliation":[{"name":"Division of Biostatistics School of Medicine, University of California Davis California"},{"name":"Department of Public Health Sciences School of Medicine, University of California Davis California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi J.","family":"Goodrich\u2010Hunsaker","sequence":"additional","affiliation":[{"name":"MIND Institute and Department of Psychiatry and Behavioral Sciences University of California Davis, Sacramento California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnson","family":"Gadelkarim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Electrical and Computer Engineering University of Illinois at Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-4828","authenticated-orcid":false,"given":"Liang","family":"Zhan","sequence":"additional","affiliation":[{"name":"LONI Department of Neurology University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Rivera","sequence":"additional","affiliation":[{"name":"MIND Institute, Department of Psychology, and University of California, Davis Center for Mind and Brain Davis California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony J.","family":"Simon","sequence":"additional","affiliation":[{"name":"MIND Institute and Department of Psychiatry and Behavioral Sciences 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