{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:10:21Z","timestamp":1788869421305,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Research Foundation (DFG)","award":["HO-2002\/10-1; Federal State of Saxony-Anhalt, Project: Center for Behavioral Brain Sciences (CBBS)."],"award-info":[{"award-number":["HO-2002\/10-1; Federal State of Saxony-Anhalt, Project: Center for Behavioral Brain Sciences (CBBS)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Congenital malformations of the optic chiasm, such as enhanced and reduced crossing of the optic nerve fibers, are evident in albinism and achiasma, respectively. In early visual cortex the resulting additional visual input from the ipsilateral visual hemifield is superimposed onto the normal retinotopic representation of the contralateral visual field, which is likely due to conservative geniculo\u2010striate projections. Counterintuitively, this organization in early visual cortex does not have profound consequences on visual function. Here we ask, whether higher stages of visual processing provide a correction to the abnormal representation allowing for largely normal perception. To this end we assessed the organization patterns of early and ventral visual cortex in five albinotic, one achiasmic, and five control participants. In albinism and achiasma the mirror\u2010symmetrical superposition of the ipsilateral and contalateral visual fields was evident not only in early visual cortex, but also in the higher areas of the ventral processing stream. Specifically, in the visual areas VO1\/2 and PHC1\/2 no differences in the extent, the degree of superposition, and the magnitude of the responses were evident in comparison to the early visual areas. Consequently, the highly atypical organization of the primary visual cortex was propagated downstream to highly specialized processing stages in an undiminished and unchanged manner. This indicates largely unaltered cortico\u2010cortical connections in both types of misrouting, i.e., enhanced and reduced crossing of the optic nerves. It is concluded that main aspects of visual function are preserved despite sizable representation abnormalities in the ventral visual processing stream.\n                    <jats:italic>Hum Brain Mapp 35:5093\u20135105, 2014<\/jats:italic>\n                    . \u00a9\n                    <jats:bold>2014 Wiley Periodicals, Inc<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/hbm.22534","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T23:47:26Z","timestamp":1398469646000},"page":"5093-5105","source":"Crossref","is-referenced-by-count":27,"title":["Impact of chiasma opticum malformations on the organization of the human ventral visual cortex"],"prefix":"10.1002","volume":"35","author":[{"given":"Falko R.","family":"Kaule","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Visual Processing Laboratory Otto\u2010von\u2010Guericke University Magdeburg Germany"},{"name":"Department of Experimental Psychology Otto\u2010von\u2010Guericke University Universit\u00e4tsplatz 2 Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wolynski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Visual Processing Laboratory Otto\u2010von\u2010Guericke University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gottlob","sequence":"additional","affiliation":[{"name":"Ophthalmology Group University of Leicester, Leicester Royal Infirmary, Robert Kilpatrick Clinical Sciences Building Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Stadler","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Neurobiology Brenneckestra\u00dfe 6 Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Speck","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Neurobiology Brenneckestra\u00dfe 6 Magdeburg Germany"},{"name":"Department Biomedical Magnetic Resonance Institute for Experimental Physics, Otto\u2010von\u2010Guericke University Magdeburg Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kanowski","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Synke","family":"Meltendorf","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Visual Processing Laboratory Otto\u2010von\u2010Guericke University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Behrens\u2010Baumann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Visual Processing Laboratory Otto\u2010von\u2010Guericke University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Visual Processing Laboratory Otto\u2010von\u2010Guericke University Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(83)90162-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00293.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.5.1195"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2807-09.2009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2793"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i10"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1507"},{"key":"e_1_2_6_9_1","article-title":"Changes in brain morphology in albinism reflect reduced visual acuity","author":"Bridge 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