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While effects of MPH on task\u2010induced brain activation have been investigated, little is known about how MPH influences the resting brain. To investigate the effects of 40 mg of oral MPH on intrinsic functional connectivity, we used resting state fMRI in 54 healthy male subjects in a double\u2010blind, randomized, placebo\u2010controlled study. Functional connectivity analysis employing ICA revealed seven resting state networks (RSN) of interest. Connectivity strength between the dorsal attention network and the thalamus was increased after MPH intake. Other RSN located in association cortex areas, such as the left and right frontoparietal networks and the executive control network, showed MPH\u2010induced connectivity increase to sensory\u2010motor and visual cortex regions and connectivity decrease to cortical and subcortical components of cortico\u2010striato\u2010thalamo\u2010cortical circuits (CST). RSN located in sensory\u2010motor cortex areas showed the opposite pattern with MPH\u2010induced connectivity increase to CST components and connectivity decrease to sensory\u2010motor and visual cortex regions. Our results provide evidence that MPH does not only alter intrinsic connectivity between brain areas involved in sustained attention, but that it also induces significant changes in the cortico\u2010cortical and cortico\u2010subcortical connectivity of many other cognitive and sensory\u2010motor RSN. <jats:italic>Hum Brain Mapp 35:5379\u20135388, 2014<\/jats:italic>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22557","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T11:43:08Z","timestamp":1400845388000},"page":"5379-5388","source":"Crossref","is-referenced-by-count":96,"title":["The effects of methylphenidate on whole brain intrinsic functional connectivity"],"prefix":"10.1002","volume":"35","author":[{"given":"Sophia","family":"Mueller","sequence":"first","affiliation":[{"name":"Institute of Clinical Radiology Ludwig\u2010Maximilians University Munich 81377 Munich 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