{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:20:29Z","timestamp":1779272429996,"version":"3.51.4"},"reference-count":78,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T00:00:00Z","timestamp":1402099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Program of National Natural Science Foundation of China","award":["91230201"],"award-info":[{"award-number":["91230201"]}]},{"name":"Marie Curie International Incoming Fellowship from the European Commission","award":["FP7-PEOPLE-2011-IIF-302421"],"award-info":[{"award-number":["FP7-PEOPLE-2011-IIF-302421"]}]},{"name":"The New Century Excellent Talents in University of China","award":["NCET-13-0139"],"award-info":[{"award-number":["NCET-13-0139"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["61273309"],"award-info":[{"award-number":["61273309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["30900404"],"award-info":[{"award-number":["30900404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["91132720"],"award-info":[{"award-number":["91132720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81000587"],"award-info":[{"award-number":["81000587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2009CB522007"],"award-info":[{"award-number":["2009CB522007"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Fund for Doctoral Program of Higher Education of China","award":["20100162120048"],"award-info":[{"award-number":["20100162120048"]}]},{"name":"Royal Society Wolfson Research Merit Award; National Centre for Mathematics and Interdisciplinary Sciences (NCMIS) of the Chinese Academy of Sciences."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Disrupted in Schizophrenia Gene 1 (<jats:italic>DISC1<\/jats:italic>) plays a role in both neural signaling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six <jats:italic>DISC1<\/jats:italic> single nucleotide polymorphisms (SNPs). We employed a brain\u2010wide association analysis (BWAS) together with a Jacknife internal validation approach in 46 schizophrenia patients and 24 matched healthy control subjects. Results from structural MRI showed significant associations between all six <jats:italic>DISC1<\/jats:italic> variants and gray matter volume in the precuneus, post\u2010central gyrus and middle cingulate gyrus. Associations with specific SNPs were found for rs2738880 in the left precuneus and right post\u2010central gyrus, and rs1535530 in the right precuneus and middle cingulate gyrus. Using regions showing structural associations as seeds a resting\u2010state functional connectivity analysis revealed significant associations between all 6 SNPS and connectivity between the right precuneus and inferior frontal gyrus. The connection between the right precuneus and inferior frontal gyrus was also specifically associated with rs821617. Importantly schizophrenia patients showed positive correlations between the six DISC\u20101 SNPs associated gray matter volume in the left precuneus and right post\u2010central gyrus and negative symptom severity. No correlations with illness duration were found. Our results provide the first evidence suggesting a key role for structural and functional connectivity associations between <jats:italic>DISC1<\/jats:italic> polymorphisms and the precuneus in schizophrenia. <jats:italic>Hum Brain Mapp 35:5414\u20135430, 2014<\/jats:italic>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22560","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T05:59:30Z","timestamp":1402120770000},"page":"5414-5430","source":"Crossref","is-referenced-by-count":30,"title":["A Brain\u2010wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia"],"prefix":"10.1002","volume":"35","author":[{"given":"Xiaohong","family":"Gong","sequence":"first","affiliation":[{"name":"Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University Shanghai 200433 China"},{"name":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Life Sciences, Fudan University Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlian","family":"Lu","sequence":"additional","affiliation":[{"name":"Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University Shanghai 200433 China"},{"name":"Centre for Scientific Computing, University of Warwick Coventry CV4 7AL United Kingdom"},{"name":"Fudan University\u2010JinLing Hospital Computational Translational Medicine Centre, Fudan University Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith M.","family":"Kendrick","sequence":"additional","affiliation":[{"name":"Key Laboratory for Neuroinformation School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu 610054 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidan","family":"Pu","sequence":"additional","affiliation":[{"name":"Medical Psychological Institute Second Xiangya Hospital Central South University Changsha 410011 China"},{"name":"Institute of Mental Health, Second Xiangya Hospital, Central South University Changsha 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Life Sciences, Fudan University Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology School of Life Sciences, Fudan University Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangmin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Nanjing University School of Medicine Nanjing 210002 PR China"},{"name":"Jinling Hospital\u2010Fudan University Computational Translational Medicine Center, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhening","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Psychological Institute Second Xiangya Hospital Central South University Changsha 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Mental Health Center, Xiangya Hospital, Central South University Changsha 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Feng","sequence":"additional","affiliation":[{"name":"Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University Shanghai 200433 China"},{"name":"Centre for Scientific Computing, University of Warwick Coventry CV4 7AL United Kingdom"},{"name":"Fudan University\u2010JinLing Hospital Computational Translational Medicine Centre, Fudan University Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.37"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-259X(85)90084-3"},{"key":"e_1_2_5_4_1","volume-title":"Handbook of Medical Image Processing and Analysis","author":"Bankman IN","year":"2008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.08.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/3318585"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm052"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3355-09.2009"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500515102"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900021295"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.01.015"},{"key":"e_1_2_5_13_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u201cpipeline\u201d data analysis of resting\u2010state fMRI","volume":"4","author":"Chao\u2010Gan Y","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.43.s50"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.37"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06482.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06973.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.03.015"},{"key":"e_1_2_5_19_1","first-page":"297","article-title":"Schizophrenia with preserved impairment is associated with increased perfusion of the precuneus","volume":"37","author":"Faget\u2010Agius C","year":"2013","journal-title":"J Psychiatry Res"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.059"},{"key":"e_1_2_5_21_1","first-page":"89","article-title":"Schizophrenia: A disconnection syndrome?","volume":"3","author":"Friston KJ","year":"1995","journal-title":"Clin Neurosci"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1007"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.269"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.3.450"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.012"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.031"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328306f2c5"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015544"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22162"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs042"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2011.00073"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.077"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.199"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.072"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09552"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr151"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20807"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21007"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/ccog.2001.0509"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1230"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.10.010"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.10.019"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs167"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000198434.06518.b8"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00799.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586440-000000000-00000"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400049101"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08020183"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.84"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.008"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.017"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0333-10.2010"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp017"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034053"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr069"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.41"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.4.379"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.495"},{"issue":"1","key":"e_1_2_5_59_1","first-page":"1","article-title":"The Jackknife\u2014A review","volume":"61","author":"Miller R","year":"1974","journal-title":"Biometrika"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.070888"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16458-1"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.01.013"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.104.2.355"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01358-0"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(99)00031-1"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.09.002"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30322"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2007.10.011"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn141"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.033670"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-012-1254-7"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203593109"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)50015-3"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.029"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04176.x"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809141106"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00485"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.05.029"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22560","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:17:27Z","timestamp":1696378647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,7]]},"references-count":78,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/hbm.22560"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22560","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,7]]}}}