{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:15:46Z","timestamp":1790399746562,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF)","award":["NRF-2013R1A2A2A01067761"],"award-info":[{"award-number":["NRF-2013R1A2A2A01067761"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. Resting state networks studies have demonstrated that dopamine modulates distinct network connectivity patterns in both a linear and a nonlinear fashion, but quantitative analyses of dopamine\u2010dependent functional connectivity secondary to PD pathology were less informative. In the present study, we performed a correlation analysis between striatal dopamine levels assessed quantitatively by FP\u2010CIT positron emission tomography imaging and resting\u2010state functional connectivity in 23 drug na\u00efve de novo patients with PD to elucidate dopamine\u2010dependent functional networks. The major finding is that the patterns of dopamine\u2010dependent positive functional connectivity varied depending on the location of striatal seeds. Dopamine\u2010dependent functional connectivity with the caudate predominantly overlay pericentral cortical areas, whereas dopamine\u2010dependent structures functionally connected with the posterior putamen predominantly involved cerebellar areas. The dorsolateral frontal area overlapped as a dopamine\u2010dependent cortical region that was positively connected with the anterior and posterior putamen. On the other hand, cortical areas where functional connectivity from the posterior cingulate was negatively correlated with dopaminergic status in the posterior putamen were localized in the left anterior prefrontal area and the parietal area. Additionally, functional connectivity between the anterior putamen and mesiofrontal areas was negatively coupled with striatal dopamine levels. The present study demonstrated that dopamine\u2010dependent functional network connectivity secondary to PD pathology mainly exhibits a consistent pattern, albeit with some variation. These patterns may reflect the diverse effects of dopaminergic medication on parkinsonian\u2010related motor and cognitive performance. <jats:italic>Hum Brain Mapp 35:5431\u20135441, 2014<\/jats:italic>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.22561","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:18:16Z","timestamp":1403025496000},"page":"5431-5441","source":"Crossref","is-referenced-by-count":34,"title":["Dopaminergic modulation of resting\u2010state functional connectivity in de novo patients with Parkinson's disease"],"prefix":"10.1002","volume":"35","author":[{"given":"KyoungWon","family":"Baik","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungho","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang\u2010Min","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun Kyung","family":"Sunwoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Yong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University Wonju College of Medicine Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Asan Medical Center, Ulsan University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Koo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil Hyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul South Korea"},{"name":"Severance Biomedical Science Institute, Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f39d0e"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2509"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112604099"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000496107"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.003"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.243"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21453"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.034"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199403000-00005"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030304"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.07.001"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20308"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.2.299"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws281"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117104109"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp178"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1544"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02744-X"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1691"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt015"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.246"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70212-X"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0810-09.2009"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20030"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1523\/JNEUROSCI.08-03-00754.1988","article-title":"Single unit analysis of the human ventral thalamic nuclear group: Correlation of thalamic \u201ctremor cells\u201d with the 3\u20136 Hz component of parkinsonian tremor","volume":"8","author":"Lenz FA","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412446202"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200109000-00002"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000180516.69442.95"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3921-07.2008"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00011-4"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00169-7"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.095224"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.9.1.126"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.8.1307"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj088"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.11.1990"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000407"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.037"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111280"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22321"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.668698"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00008"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00783.2009"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp245"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1406"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0046984"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:18:15Z","timestamp":1696378695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/hbm.22561"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22561","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,17]]}}}