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To identify hemodynamic alteration related to severe intracranial arterial stenosis (SIAS), functional MRI of cerebrovascular reserve (CVR BOLD fMRI) to hypercapnia has been proposed. Diffusion imaging suggests chronic low grade ischemia in patients with impaired CVR. The aim of the present study was to evaluate how oxygen parameters (StO<jats:sub>2<\/jats:sub> and CMRO<jats:sub>2<\/jats:sub>), assessed with mqBOLD approach, correlate with CVR in patients (<jats:italic>n<\/jats:italic>\u2009=\u200912) with SIAS and without arterial occlusion. The perfusion (dynamic susceptibility contrast), oxygenation, and CVR were compared. The MRI protocol conducted at 3T lasted approximately 1 h. Regions of interest measures on maps were delineated on segmented gray matter (GM) of middle cerebral artery territories. We have shown that decreased CVR is spatially associated with decreased CMRO<jats:sub>2<\/jats:sub> in GM of patients with SIAS. Further, the degree of ipsilateral CVR reduction was well\u2010correlated with the amplitude of the CMRO<jats:sub>2<\/jats:sub> deficit. The altered CMRO<jats:sub>2<\/jats:sub> suggests the presence of a moderate ischemia explained by both a decrease in perfusion and in CVR. CVR and mqBOLD method may be helpful in the selection of patients with SIAS to advocate for medical therapy or percutaneous transluminal angioplasty\u2010stenting. <jats:italic>Hum Brain Mapp 36:695\u2013706, 2015<\/jats:italic>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22657","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T08:04:11Z","timestamp":1413101051000},"page":"695-706","source":"Crossref","is-referenced-by-count":35,"title":["Reduced CMRO<sub>2<\/sub> and cerebrovascular reserve in patients with severe intracranial arterial stenosis: A combined multiparametric qBOLD oxygenation and BOLD fMRI study"],"prefix":"10.1002","volume":"36","author":[{"given":"Julien","family":"Bouvier","sequence":"first","affiliation":[{"name":"Inserm, U836 Grenoble France"},{"name":"Universit\u00e9 Grenoble Alpes, Grenoble Institute of Neurosciences Grenoble France"},{"name":"Philips France (Healthcare Activity) 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