{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:46:13Z","timestamp":1790815573469,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta\u2010analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task\u2010based fMRI studies in MCI and AD published between January 1990 and January 2014. Activation likelihood estimation meta\u2010analyses were conducted to compare the significant group differences in brain activation, the significant voxels were overlaid onto seven referenced neuronal cortical networks derived from the resting\u2010state fMRI data of 1,000 healthy participants. Thirty\u2010nine task\u2010based fMRI studies (697 MCI patients and 628 healthy controls) were included in MCI\u2010related meta\u2010analysis while 36 task\u2010based fMRI studies (421 AD patients and 512 healthy controls) were included in AD\u2010related meta\u2010analysis. The meta\u2010analytic results revealed that MCI and AD showed abnormal regional brain activation as well as large\u2010scale brain networks. MCI patients showed hypoactivation in default, frontoparietal, and visual networks relative to healthy controls, whereas AD\u2010related hypoactivation mainly located in visual, default, and ventral attention networks relative to healthy controls. Both MCI\u2010related and AD\u2010related hyperactivation fell in frontoparietal, ventral attention, default, and somatomotor networks relative to healthy controls. MCI and AD presented different pathological while shared similar compensatory large\u2010scale networks in fulfilling the cognitive tasks. These system\u2010level findings are helpful to link the fundamental declines of cognitive tasks to brain networks in MCI and AD. <jats:italic>Hum Brain Mapp 36:1217\u20131232, 2015.<\/jats:italic> <jats:bold>\u00a9 2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22689","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:08:16Z","timestamp":1416467296000},"page":"1217-1232","source":"Crossref","is-referenced-by-count":187,"title":["Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta\u2010analysis of 75 fMRI studies"],"prefix":"10.1002","volume":"36","author":[{"given":"Hui\u2010Jie","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Hui","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 China"},{"name":"University of Chinese Academy of Sciences Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Youth Work Department China Youth University of Political Studies Beijing 100089 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Lin","family":"Yue","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Soochow University Suzhou 215006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning &amp; IDG\/McGovern Institute for Brain Research Beijing Normal University Beijing 100875 China"},{"name":"Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal University Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Nian","family":"Zuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 China"},{"name":"Center for Collaboration and Innovation in Brain and Learning Sciences Beijing Normal University Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.107.s179.7.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111256"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.08.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2541090558"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091054"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.05.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.04.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5698-11.2012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.12.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2250-06.2006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12177"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.3233\/JAD-2012-120730","article-title":"Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer's disease","volume":"3","author":"Chhatwal JP","year":"2012","journal-title":"J Alzheimers Dis 31(Suppl"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00270.2012"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03331976"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-110426"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.06.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3470"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl228"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11101521"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2007.04.005"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh413"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1036-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/610392"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs093"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.01.001"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.135"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.07.023"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617712000689"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh400"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2049"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.045"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10157"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.17.4.658"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg027"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.08.008"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.034"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858409334423"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.01.012"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2005.09.005"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.3.425"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_6_53_1","article-title":"Visuospatial processing in early Alzheimer's disease","author":"Jacobs HI","journal-title":"A multimodal neuroimaging study"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.009"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.09.017"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.07.007"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70277-5"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.812"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2007.11.009"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104877"},{"key":"e_1_2_6_61_1","first-page":"1006","article-title":"Cortical activation during cholinesterase\u2010inhibitor treatment in Alzheimer disease\u2014Preliminary findings from a pharmaco\u2010fMRI study","volume":"13","author":"Kircher TTJ","year":"2005","journal-title":"Am J Geriat Psychiatry"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.013"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322112"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20136"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.06.018"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.09.006"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-06-01799.1987"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000197930"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.11.003"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21269"},{"key":"e_1_2_6_72_1","first-page":"39","article-title":"Multimodal intervention in older adults improves resting\u2010state functional connectivity between the medial prefrontal cortex and medial temporal lobe","volume":"10","author":"Li R","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113106660172"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147471"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090523"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.08.024"},{"key":"e_1_2_6_77_1","first-page":"465","article-title":"Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease","volume":"4","author":"McGeown WJ","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.082"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb00187.x"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.04.021"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2012.11.005"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20653"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-76"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-013-0239-6"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2401050739"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451061847"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318162a0a9"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181a785c9"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.05.027"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.025"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.12.122"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.045"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2013.00105"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20160"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1398-4"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561779955501X"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.11.024"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.02.005"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00789.x"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054625"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.44"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.002"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.11.002"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275674"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199907)14:7<556::AID-GPS982>3.0.CO;2-4"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1159\/000148190"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1131"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21186"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054035"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e31827de67f"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj179"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.02.003"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.04.013"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0b013e3182462ea6"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000296941.06685.22"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.033"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2011_159"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-2794-x"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.04.011"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq075"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121879"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22689","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:05:49Z","timestamp":1696604749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,19]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/hbm.22689"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22689","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,19]]}}}