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Results from existing functional brain imaging studies using disorder\u2010relevant food\u2010 or body\u2010stimuli have been heterogeneous and may be biased due to varying compliance or strategies of the participants. In this study, resting state functional connectivity imaging was used. To explore the distributed nature and complexity of brain function we characterized network patterns in patients with acute AN. Thirty\u2010five unmedicated female acute AN patients and 35 closely matched healthy female participants underwent resting state functional magnetic resonance imaging. We used a network\u2010based statistic (NBS) approach [Zalesky et al., 2010a] to identify differences between groups by isolating a network of interconnected nodes with a deviant connectivity pattern. Group comparison revealed a subnetwork of connections with decreased connectivity including the amygdala, thalamus, fusiform gyrus, putamen and the posterior insula as the central hub in the patient group. Results were not driven by changes in intranodal or global connectivity. No network could be identified where AN patients had increased coupling. Given the known involvement of the identified thalamo\u2010insular subnetwork in interoception, decreased connectivity in AN patients in these nodes might reflect changes in the propagation of sensations that alert the organism to urgent homeostatic imbalances and pain\u2010processes that are known to be severely disturbed in AN and might explain the striking discrepancy between patient's actual and perceived internal body state.  <jats:italic>Hum Brain Mapp 36:1772\u20131781, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.22736","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T06:33:11Z","timestamp":1421908391000},"page":"1772-1781","source":"Crossref","is-referenced-by-count":65,"title":["Reduced functional connectivity in the thalamo\u2010insular subnetwork in patients with acute anorexia nervosa"],"prefix":"10.1002","volume":"36","author":[{"given":"Stefan","family":"Ehrlich","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Eating Disorder Services and Research Center, Technische Universit\u00e4t Dresden, Faculty of Medicine, University Hospital C. 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