{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:31:13Z","timestamp":1782509473447,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Netherlands Organisation for Scientific Research (NWO)","award":["VIDI Grant 639.072.411"],"award-info":[{"award-number":["VIDI Grant 639.072.411"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate both cross\u2010sectional and time\u2010related changes of striatal and whole\u2010brain microstructural properties in different stages of Huntington's disease (HD) using diffusion tensor imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental design<\/jats:title><jats:p>From the TRACK\u2010HD study, premanifest gene carriers (preHD), early manifest HD and controls were scanned at baseline and 2\u2010year follow\u2010up. Stratification of the preHD group into a far (preHD\u2010A) and near (preHD\u2010B) to predicted disease onset was performed. Age\u2010corrected histograms of whole\u2010brain white matter (WM), gray matter (GM) and striatal diffusion measures were computed and normalised by the number of voxels in each subject's data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Principle observations<\/jats:title><jats:p>Higher cross\u2010sectional mean, axial and radial diffusivities were found in both WM (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001) and GM (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001) of the manifest HD compared to the preHD and control groups. In preHD, only WM axial diffusivity (AD) was higher than in controls (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01). This finding remained valid only in preHD\u2010B (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001). AD was also higher in the striatum of preHD\u2010B compared to controls and preHD\u2010A (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01). Fractional anisotropy (FA) lacked sensitivity in differentiating between the groups. Histogram peak heights were generally lower in manifest HD compared to the preHD and control groups. No longitudinal differences were found in the degree of diffusivity change between the groups in the two year follow\u2010up. There was a significant relationship between diffusivity and neurocognitive measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alterations in cross\u2010sectional diffusion profiles between manifest HD subjects and controls were evident, both in whole\u2010brain and striatum. In the preHD stage, only AD alterations were found, a finding suggesting that this metric is a sensitive marker for early change in HD prior to disease manifestation. The individual diffusivities were superior to FA in revealing pathologic microstructural brain alterations. Diffusion measures were well related to clinical functioning and disease stage. <jats:italic>Hum Brain Mapp 36:2061\u20132074, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/hbm.22756","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T05:54:54Z","timestamp":1422942894000},"page":"2061-2074","source":"Crossref","is-referenced-by-count":36,"title":["Microstructural brain abnormalities in Huntington's disease: A two\u2010year follow\u2010up"],"prefix":"10.1002","volume":"36","author":[{"given":"Omar F. 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