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The cortical regions are connected via several cortico\u2010to\u2010cortical tracts impacting syntactic processing (e.g., the arcuate) but it remains unclear whether and how the striatum can be integrated into this cortex\u2010centered syntax network. Here, we used a systematic stepwise approach to investigate the existence and syntactic function of an additional deep Broca\u2010striatum pathway. We first asked 15 healthy controls and 12 patients with frontal\/striatal lesions to perform three syntax tests. The results obtained were subjected to voxel\u2010based lesion\u2010symptom mapping (VLSM) to provide an anatomo\u2010functional approximation of the pathway. The significant VLSM clusters were then overlapped with the probability maps of four cortico\u2010cortical language tracts generated for 12 healthy participants (arcuate, extreme capsule fiber system, uncinate, aslant), including a probabilistic Broca\u2010striatum tract. Finally, we carried out quantitative analyses of the relationship between the lesion load along the tracts and syntactic processing, by calculating tract\u2010lesion overlap for each patient and analyzing the correlation with syntactic data. Our findings revealed a Broca\u2010striatum tract linking BA45 with the left caudate head and overlapping with VLSM voxel clusters relating to complex syntax. The lesion load values for this tract were correlated with complex syntax scores, whereas no such correlation was observed for the other tracts. These results extend current syntax\u2010network models, by adding a deep \u201cBroca\u2010caudate pathway,\u201d and are consistent with functional accounts of frontostriatal circuits. <jats:italic>Hum Brain Mapp 36:2270\u20132283, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22769","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T08:15:10Z","timestamp":1424074510000},"page":"2270-2283","source":"Crossref","is-referenced-by-count":60,"title":["A cortical\u2013subcortical syntax pathway linking <scp>B<\/scp>roca's area and the striatum"],"prefix":"10.1002","volume":"36","author":[{"given":"Marc","family":"Teichmann","sequence":"first","affiliation":[{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure D\u00e9partement d'Etudes Cognitives Paris France"},{"name":"AP\u2010HP, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, D\u00e9partement de Neurologie, Centre de r\u00e9f\u00e9rence \u201cD\u00e9mences Rares\u201d Paris France"},{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"CRICM\u2014Centre de Recherche de l'Institut du Cerveau et de la Moelle \u00e9pini\u00e8re UPMC Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rosso","sequence":"additional","affiliation":[{"name":"CRICM\u2014Centre de Recherche de l'Institut du Cerveau et de la Moelle \u00e9pini\u00e8re UPMC Paris 6 Paris France"},{"name":"Inserm U1127, CNRS, UMR 7225 Paris France"},{"name":"COGIMAGE UPMC Paris 6 Paris France"},{"name":"AP\u2010HP, Urgences C\u00e9r\u00e9bro\u2010Vasculaires, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Martini","sequence":"additional","affiliation":[{"name":"T\u00e9l\u00e9com ParisTech, CNRS LTCI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bloch","sequence":"additional","affiliation":[{"name":"T\u00e9l\u00e9com ParisTech, CNRS LTCI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Brugi\u00e8res","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Henri Mondor\u2014Albert Chenevier, Service de neuroradiologie Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Duffau","sequence":"additional","affiliation":[{"name":"INSERM U583, Institut des Neurosciences de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Leh\u00e9ricy","sequence":"additional","affiliation":[{"name":"CRICM\u2014Centre de Recherche de l'Institut du Cerveau et de la Moelle \u00e9pini\u00e8re UPMC Paris 6 Paris France"},{"name":"Inserm U1127, CNRS, UMR 7225 Paris France"},{"name":"Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, Centre de Neuro\u2010Imagerie de Recherche (CENIR) Paris France"},{"name":"APHP, Service de Neuroradiologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Catherine","family":"Bachoud\u2010L\u00e9vi","sequence":"additional","affiliation":[{"name":"INSERM U955 Equipe 01 Neuropsychologie interventionnelle Cr\u00e9teil France"},{"name":"Ecole Normale Sup\u00e9rieure D\u00e9partement d'Etudes Cognitives Paris France"},{"name":"Universit\u00e9 Paris Est, Facult\u00e9 de M\u00e9decine Cr\u00e9teil France"},{"name":"AP\u2010HP, H\u00f4pital Henri Mondor\u2010Albert Chenevier, Centre de r\u00e9f\u00e9rence maladie de Huntington 94000 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.01.002"},{"key":"e_1_2_6_3_1","volume-title":"Level set deformable models constrained by fuzzy spatial relations. 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