{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:21:02Z","timestamp":1767651662472,"version":"3.41.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["5R37AG-006265-25 (D.C.P.)","3R37AG-006265-25S1 (D.C.P.)","4 R00-AG-036818-04 (K.M.K.)","R00-AG-36848-04 (K.M.R.)"],"award-info":[{"award-number":["5R37AG-006265-25 (D.C.P.)","3R37AG-006265-25S1 (D.C.P.)","4 R00-AG-036818-04 (K.M.K.)","R00-AG-36848-04 (K.M.R.)"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","award":["IIRG-09-135087 (D.C.P.)"],"award-info":[{"award-number":["IIRG-09-135087 (D.C.P.)"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The recent ability to measure<jats:italic>in vivo<\/jats:italic>beta\u2010amyloid (A\u03b2), a marker of Alzheimer's disease (AD), has led to an increased focus on the significance of A\u03b2 deposition in clinically normal adults. Evidence suggests that healthy adults with elevated cortical A\u03b2 show differences in neural activity associated with memory encoding\u2014specifically encoding of face stimuli. Here, we examined if A\u03b2 deposition in clinically normal adults was related to differences in neural activity in ventral visual cortex during face viewing. Our sample included 23 high\u2010A\u03b2 older adults, 23 demographically matched low\u2010A\u03b2 older adults, and 16 young adults. Participants underwent cognitive testing, A\u03b2 positron emission tomography imaging with<jats:sup>18<\/jats:sup>F\u2010Florbetapir, and functional magnetic resonance imaging to measure neural activity while participants passively viewed photographs of faces. Using barycentric discriminant analysis\u2014a between\u2010groups classification technique\u2014we found that patterns of neural activity in the left fusiform gyrus, a region highly responsive to faces, distinguished A\u03b2 status of participants. Older adults with elevated A\u03b2 were characterized by decreased activity in left fusiform compared to A\u03b2\u2010negative older adults. Further, we found that the degree to which older adults expressed decreased fusiform activity was related to worse performance on tasks of processing speed. Our results provide unique evidence that, in addition to previously studied memory and default regions<jats:bold>,<\/jats:bold>decreased neural activity in a region important for face perception was associated with elevated A\u03b2 and may be an early manifestation of AD.<jats:italic>Hum Brain Mapp 36:2514\u20132526, 2015<\/jats:italic>. \u00a9<jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.22788","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:13:56Z","timestamp":1428012836000},"page":"2514-2526","source":"Crossref","is-referenced-by-count":25,"title":["The effect of beta\u2010amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal"],"prefix":"10.1002","volume":"36","author":[{"given":"Jenny R.","family":"Rieck","sequence":"first","affiliation":[{"name":"Center for Vital Longevity School of Behavioral and Brain Sciences University of Texas at Dallas Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Rodrigue","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity School of Behavioral and Brain Sciences University of Texas at Dallas Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen M.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity School of Behavioral and Brain Sciences University of Texas at Dallas Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Sr.","given":"Michael D.","family":"Devous","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise C.","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity School of Behavioral and Brain Sciences University of Texas at Dallas Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"907","article-title":"Singular value decomposition (SVD) and generalized singular value decomposition","author":"Abdi H","year":"2007","journal-title":"Encyclopedia of Measurement and Statistics."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.11.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-112111"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/634165"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.1246"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1509"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"BeatonD RieckJR AbdiH(2013): TInPosition: Inference tests for TExPosition (version 2.6.10) [Software]. Available fromhttp:\/\/cran.r-project.org\/web\/packages\/TInPosition\/index.html","DOI":"10.32614\/CRAN.package.InPosition"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2013.11.006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.177"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl051"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.08.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854049108403297"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.267"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.2008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr066"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177013815"},{"key":"e_1_2_6_19_1","unstructured":"EkstromRB FrenchJW HarmanH DermanD(1976): Kit of factor\u2010referenced cognitive tests (rev ed.) Princeton NJ: Educational Testing Service."},{"key":"e_1_2_6_20_1","first-page":"13","article-title":"Effects of beta\u2010amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability","volume":"1","author":"Elman JA","year":"2014","journal-title":"Cereb Cortex"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.01.107"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/90565"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144220"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063736"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.16.1.65"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3189-09.2009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828ab35d"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.182"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3579-13.2014"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.040"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq277"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.077"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.034"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00026"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0016"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.05.018"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.020"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-113011-143804"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03206543"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr025"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr255"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.098"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.269"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2014.911351"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.2.299"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405148101"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.59.103006.093656"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0853-10.2010"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4494-11.2012"},{"volume-title":"Manual for Raven's Progressive Matrices and Vocabulary Scales Section 1: General Overview","year":"1998","author":"Raven J","key":"e_1_2_6_55_1"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.06.006"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106735"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-009-9118-x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318245d295"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.007"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl102"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.024"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.009"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.003"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0749-596X(89)90040-5"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.01.003"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs108"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.09.051"},{"volume-title":"WAIS\u2010III administration and scoring manual","year":"1997","author":"Wechsler D","key":"e_1_2_6_71_1"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.044"},{"volume-title":"Shipley Institute of Living Scale Revised Manual","year":"1986","author":"Zachary A","key":"e_1_2_6_73_1"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22788","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.22788","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T21:12:34Z","timestamp":1747861954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,2]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/hbm.22788"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22788","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"type":"print","value":"1065-9471"},{"type":"electronic","value":"1097-0193"}],"subject":[],"published":{"date-parts":[[2015,4,2]]}}}