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We applied a graph\u2010theory method to the resting\u2010state functional magnetic resonance imaging data of 120 children with ADHD and 120 age\u2010matched typically developing children (TDC). Starting in unimodal primary cortex\u2014visual, auditory, and somatosensory\u2014we used stepwise functional connectivity to calculate functional connectivity paths at discrete numbers of relay stations (or link\u2010step distances). First, we characterized the functional connectivity streams that link sensory, attentional, and higher\u2010order cognitive circuits in TDC and found that systems do not reach the level of integration achieved by adults. Second, we searched for stepwise functional connectivity differences between children with ADHD and TDC. We found that, at the initial steps of sensory functional connectivity streams, patients display significant enhancements of connectivity degree within neighboring areas of primary cortex, while connectivity to attention\u2010regulatory areas is reduced. Third, at subsequent link\u2010step distances from primary sensory cortex, children with ADHD show decreased connectivity to executive processing areas and increased degree of connections to default mode regions. Fourth, in examining medication histories in children with ADHD, we found that children medicated with psychostimulants present functional connectivity streams with higher degree of connectivity to regions subserving attentional and executive processes compared to medication\u2010na\u00efve children. We conclude that predominance of local sensory processing and lesser influx of information to attentional and executive regions may reduce the ability to organize and control the balance between external and internal sources of information in ADHD. <jats:italic>Hum Brain Mapp 36:2544\u20132557, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.22790","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T07:10:39Z","timestamp":1427613039000},"page":"2544-2557","source":"Crossref","is-referenced-by-count":51,"title":["Sensation\u2010to\u2010cognition cortical streams in attention\u2010deficit\/hyperactivity disorder"],"prefix":"10.1002","volume":"36","author":[{"given":"Susana","family":"Carmona","sequence":"first","affiliation":[{"name":"Department of Psychology Harvard University, Center for Brain Science Cambridge Massachusetts"},{"name":"Unidad de Medicina y Cirug\u00eda Experimental, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial Universidad Carlos III de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elseline","family":"Hoekzema","sequence":"additional","affiliation":[{"name":"Neuroendocrinology Bakker Group Netherlands Institute for Neuroscience Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco X.","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Center for Neurodevelopmental Disorders, The Child Study Center at NYU Langone Medical Center New York New York"},{"name":"Division of Child and Adolescent Psychiatric Research Nathan Kline Institute for Psychiatric Research Orangeburg New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Medicina y Cirug\u00eda Experimental, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial Universidad Carlos III de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Lage\u2010Castellanos","sequence":"additional","affiliation":[{"name":"Department of Neurostatistics, Cuba Neuroscience Center Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koene R.A.","family":"Van Dijk","sequence":"additional","affiliation":[{"name":"Department of Psychology Harvard University, Center for Brain Science Cambridge Massachusetts"},{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Charlestown Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Navas\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial Universidad Carlos III de Madrid Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenia","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Medicina y Cirug\u00eda Experimental, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Desco","sequence":"additional","affiliation":[{"name":"Unidad de Medicina y Cirug\u00eda Experimental, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial Universidad Carlos III de Madrid Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM)  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sepulcre","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. 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