{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:03:19Z","timestamp":1792605799498,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T00:00:00Z","timestamp":1427500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Healthy","award":["#RF-2010-2313220 and #GR-2010-2303035"],"award-info":[{"award-number":["#RF-2010-2313220 and #GR-2010-2303035"]}]},{"name":"CurePSP Foundation","award":["#MD505-12_001."],"award-info":[{"award-number":["#MD505-12_001."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To identify overlapping and unique grey (GM) and white matter (WM) signatures within the frontotemporal lobar degeneration (FTLD) continuum, and discriminate likely FTLD\u2010TAU and FTLD\u2010TDP patients using structural and diffusion tensor (DT) magnetic resonance imaging (MRI). <jats:italic>Methods<\/jats:italic>. T1\u2010weighted and DT MRI were collected from 121 subjects: 35 motor neuron disease (MND), 14 behavioral variant of frontotemporal dementia, 12 semantic and 11 nonfluent primary progressive aphasia, 21 progressive supranuclear palsy syndrome patients, and 28 healthy controls. Patterns of GM atrophy were established using voxel\u2010based morphometry. Tract\u2010based spatial statistics was used to perform a WM voxelwise analysis of mean diffusivity and fractional anisotropy. <jats:italic>Results<\/jats:italic>. In all clinical FTLD phenotypes, the pattern of WM damage was more distributed than that of GM atrophy. All patient groups, with the exception of MND cases with a pure motor syndrome, shared a focal GM atrophy centered around the dorsolateral and medial frontal cortex and a largely overlapping pattern of WM damage involving the genu and body of the corpus callosum and ventral frontotemporal and dorsal frontoparietal WM pathways. Surrounding this common area, phenotype (symptom)\u2010specific GM and WM regions of damage were found in each group. <jats:italic>Conclusions<\/jats:italic>. In the FTLD spectrum, WM disruption is more severe than GM damage. Frontal cortex and WM pathways represent the common target of neurodegeneration in these conditions. The topographic pattern of damage supports a \u201cprion\u2010like\u201d protein propagation through WM connections as underlying mechanism of the stereotyped progression of FTLD. <jats:italic>Hum Brain Mapp 36:2602\u20132614, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22794","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T07:10:50Z","timestamp":1427613050000},"page":"2602-2614","source":"Crossref","is-referenced-by-count":55,"title":["MRI signatures of the frontotemporal lobar degeneration continuum"],"prefix":"10.1002","volume":"36","author":[{"given":"Federica","family":"Agosta","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Galantucci","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Experimental Neurology, Division of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Marcone","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Antonietta Volont\u00e8","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Experimental Neurology, Division of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Experimental Neurology, Division of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar M.","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Caso","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Chi\u00f2","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, ALS Center \u201cRita Levi Montalcini\u201d University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Experimental Neurology, Division of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Falini","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and CERMAC San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit"},{"name":"Department of Neurology Institute of Experimental Neurology, Division of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.04.012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr288"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23937"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1238-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.03.026"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000031"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70167-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12044"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828407bc"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61154-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr099"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","unstructured":"IrwinDJ CairnsNJ GrossmanM McMillanCT LeeEB VanDeerlinVM LeeVM TrojanowskiJQ: Frontotemporal lobar degeneration: Defining phenotypic diversity through personalized medicine. Acta Neuropathol (in press). [epub ahead of print 31 Dec 2014; doi: 10.1007\/s00401-014-1380-1]","DOI":"10.1007\/s00401-014-1380-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.6.513"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.114231"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043993"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304418"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000248554.45456.58"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.06.007"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.09.009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.2.495"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132288"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr198"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt118"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.38"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.007"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802654364"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102656"},{"key":"e_1_2_6_41_1","first-page":"601\u2013619","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)\u2010PK11195 positron emission tomography study","volume":"15","year":"2004","journal-title":"Neurobiol Dis"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.107"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64390-8"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20916"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.22794","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:53:13Z","timestamp":1693936393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,28]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/hbm.22794"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22794","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,28]]}}}