{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:48:07Z","timestamp":1791226087609,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["GR-2009-1529671"],"award-info":[{"award-number":["GR-2009-1529671"]}]},{"DOI":"10.13039\/100007366","name":"Fondazione Italiana Sclerosi Multipla","doi-asserted-by":"crossref","award":["FISM2011\/R19"],"award-info":[{"award-number":["FISM2011\/R19"]}],"id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dutch MS Research Foundation","award":["09-538d"],"award-info":[{"award-number":["09-538d"]}]},{"name":"MAGNIMS-ECTRIMS Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this multicenter study, we performed a tractography\u2010based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual\u2010echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing\u2010remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography\u2010based parcellation. Between\u2010group differences of CDRs and cortico\u2010thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic shape was also performed. A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains. Twenty\u2010two (43%) MS patients were cognitively impaired (CI). Compared to cognitively preserved, CI MS patients had increased fractional anisotropy of frontal, motor, postcentral and occipital connected CDRs (0.002&lt;<jats:italic>P<\/jats:italic>&lt;0.02). They also experienced more pronounced atrophy in anterior thalamic regions and abnormal DT MRI indices of all cortico\u2010thalamic tracts. Damage of specific cortico\u2010thalamic tracts explained global cognitive dysfunction and impairment of selected cognitive domains better than all other MRI variables. Thalamic CDR DT MRI abnormalities were correlated with abnormalities of the corresponding cortico\u2010thalamic tracts. Cortico\u2010thalamic disconnection is, at various levels, implicated in cognitive dysfunction in MS. Thalamic involvement in CI MS patients is likely related to gray matter rather than white matter damage of thalamic subregions. <jats:italic>Hum Brain Mapp 36:2809\u20132825, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22809","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T03:53:46Z","timestamp":1429070026000},"page":"2809-2825","source":"Crossref","is-referenced-by-count":85,"title":["Connectivity\u2010based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment: A multicenter study"],"prefix":"10.1002","volume":"36","author":[{"given":"Alvino","family":"Bisecco","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"I Division of Neurology, Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples Naples Italy"},{"name":"MRI Center \u201cSUN\u2010FISM,\u201d Second University of Naples and Institute of Diagnosis and Care \u201cHermitage\u2010Capodimonte,\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Rocca","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Pagani","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mancini","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Enzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gallo","sequence":"additional","affiliation":[{"name":"I Division of Neurology, Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples Naples Italy"},{"name":"MRI Center \u201cSUN\u2010FISM,\u201d Second University of Naples and Institute of Diagnosis and Care \u201cHermitage\u2010Capodimonte,\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vrenken","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine MS Centre Amsterdam, VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Stromillo","sequence":"additional","affiliation":[{"name":"Department of Neurological and Behavioral Sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Copetti","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit, UCL Institute of Neurology, Queen Square London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"I Division of Neurology, Department of Medical Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples Naples Italy"},{"name":"MRI Center \u201cSUN\u2010FISM,\u201d Second University of Naples and Institute of Diagnosis and Care \u201cHermitage\u2010Capodimonte,\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine MS Centre Amsterdam, VU University Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Department of Neurological and Behavioral Sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology Division of Neuroscience, San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience San Raffaele Scientific Institute, Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"MAGNIMS Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1037"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6147-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1075"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.2.226"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.9.1301"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513478675"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/135245850100700409"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.04.054"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110195"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.12.031"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3788"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22214"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70259-X"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.7.926"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20969"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn275"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11111299"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512457842"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1977.44.2.367"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2983"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(95)00077-1"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-07-02393.2001"},{"key":"e_1_2_5_27_1","unstructured":"HeatonRK CheluneGJ TalleyJL KayGG CurtisG(1993): Wisconsin Card sorting test (WCST) manual revised and expanded. Odessa FL. Psychological Assessment Resources."},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.134825"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000276992.17011.b5"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.043"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726cc"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh105"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1101"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10331"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20033"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1201oa"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22470"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.09.024"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20692"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2430"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824d5859"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b910b"},{"key":"e_1_2_5_45_1","first-page":"1445","article-title":"Diffusion\u2010tensor MR imaging of gray and white matter development during normal human brain maturation","volume":"23","author":"Mukherjee P","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-34686-9"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.008"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22186"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9160-9"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.057"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070486"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854040801992815"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.5.685"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10308"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22586"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.8.1175"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1040"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1696526"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022051"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131688"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1564"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.024"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.10.005"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.9.868"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.03.010"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.053"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22809","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.22809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:53:00Z","timestamp":1693936380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/hbm.22809"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22809","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}