{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:03:32Z","timestamp":1778126612583,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81401400 [to G.J.J.], 81020109002 and 31471084 [to Y.F.Z.], 81201155 and 81471653 [to W.L.]"],"award-info":[{"award-number":["81401400 [to G.J.J.], 81020109002 and 31471084 [to Y.F.Z.], 81201155 and 81471653 [to W.L.]"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Planning Project of Zhejiang Province, China","award":["2014C33189 [to Y.T.]"],"award-info":[{"award-number":["2014C33189 [to Y.T.]"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2013M532229 [to W.L.]."],"award-info":[{"award-number":["2013M532229 [to W.L.]."]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benign epilepsy with centrotemporal spikes (BECTS) is often associated with neural circuit dysfunction, particularly during the transient active state characterized by interictal epileptiform discharges (IEDs). Little is known, however, about the functional neural circuit abnormalities in BECTS without IEDs, or if such abnormalities could be used to differentiate BECTS patients without IEDs from healthy controls (HCs) for early diagnosis. To this end, we conducted resting\u2010state functional magnetic resonance imaging (RS\u2010fMRI) and simultaneous Electroencephalogram (EEG) in children with BECTS (<jats:italic>n<\/jats:italic>\u2009=\u200943) and age\u2010matched HC (<jats:italic>n<\/jats:italic>\u2009=\u200928). The simultaneous EEG recordings distinguished BECTS with IEDs (<jats:italic>n<\/jats:italic>\u2009=\u200920) from without IEDs (<jats:italic>n<\/jats:italic>\u2009=\u200923). Intrinsic brain activity was measured in all three groups using the amplitude of low frequency fluctuation at rest. Compared to HC, BECTS patients with IEDs exhibited an intrinsic activity abnormality in the thalamus, suggesting that thalamic dysfunction could contribute to IED emergence while patients without IEDs exhibited intrinsic activity abnormalities in middle frontal gyrus and superior parietal gyrus. Using multivariate pattern classification analysis, we were able to differentiate BECTS without IEDs from HCs with 88.23% accuracy. BECTS without epileptic transients can be distinguished from HC and BECTS with IEDs by unique regional abnormalities in resting brain activity. Both transient abnormalities as reflected by IEDs and chronic abnormalities as reflected by RS\u2010fMRI may contribute to BECTS development and expression. Intrinsic brain activity and multivariate pattern classification techniques are promising tools to diagnose and differentiate BECTS syndromes. <jats:italic>Hum Brain Mapp 36:3878\u20133889, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22884","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:17:00Z","timestamp":1436879820000},"page":"3878-3889","source":"Crossref","is-referenced-by-count":42,"title":["Intrinsic brain activity as a diagnostic biomarker in children with benign epilepsy with centrotemporal spikes"],"prefix":"10.1002","volume":"36","author":[{"given":"Yihong","family":"Zhu","sequence":"first","affiliation":[{"name":"Mental Health Education and Counseling Center Zhejiang University  Zhejiang China"},{"name":"School of Public Health, Zhejiang University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Mental Health Education and Counseling Center Zhejiang University  Zhejiang China"},{"name":"School of Public Health, Zhejiang University  Zhejiang China"},{"name":"Center for Cognition and Brain Disorders and the Affiliated Hospital Hangzhou Normal University  Zhejiang China"},{"name":"Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments  Zhejiang China"},{"name":"Department of Psychiatry the Second Affiliated Hospital of Medial College, Zhejiang University  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana V.","family":"Shinkareva","sequence":"additional","affiliation":[{"name":"Department of Psychology University of South Carolina Columbia South 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