{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:37:08Z","timestamp":1791549428365,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto de Salud, Carlos III, Gobierno de Espa\u00f1a Project Grants","award":["PI12\/0136 to NC and PI12\/00273 to MF"],"award-info":[{"award-number":["PI12\/0136 to NC and PI12\/00273 to MF"]}]},{"name":"LIIRA Program Grant","award":["WS717052 to NC"],"award-info":[{"award-number":["WS717052 to NC"]}]},{"name":"National Health and Medical Research Council of Australia (NHMRC) Project Grant","award":["1025619 to BJH"],"award-info":[{"award-number":["1025619 to BJH"]}]},{"name":"NHMRC Clinical Career Development Fellowship","award":["628509 to BJH"],"award-info":[{"award-number":["628509 to BJH"]}]},{"name":"Instituto de Salud, Carlos III, Gobierno de Espa\u00f1a \u2018Miguel Servet\u2019 contract","award":["CP10\/00604 to CSM"],"award-info":[{"award-number":["CP10\/00604 to CSM"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that human trait anxiety sensitivity (AS)\u2014the fear of bodily autonomic arousal\u2014is primarily mediated by the anterior insular cortex. Despite broad appeal, few experimental studies have comprehensively addressed this hypothesis. We recruited 55 individuals exhibiting a range of AS and assessed them with functional magnetic resonance imaging (fMRI) during aversive fear conditioning. For each participant, three primary measures of interest were derived: a trait Anxiety Sensitivity Index score; an in\u2010scanner rating of elevated bodily anxiety sensations during fear conditioning; and a corresponding estimate of whole\u2010brain functional activation to the conditioned versus nonconditioned stimuli. Using a voxel\u2010wise mediation analysis framework, we formally tested for \u2018neural mediators\u2019 of the predicted association between trait AS score and in\u2010scanner anxiety sensations during fear conditioning. Contrary to the anterior insular hypothesis, no evidence of significant mediation was observed for this brain region, which was instead linked to perceived anxiety sensations independently from AS. Evidence for significant mediation was obtained for the dorsal anterior cingulate cortex\u2014a finding that we argue is more consistent with the hypothesized role of human cingulofrontal cortex in conscious threat appraisal processes, including threat\u2010overestimation. This study offers an important neurobiological validation of the AS construct and identifies a specific neural substrate that may underlie high AS clinical phenotypes, including but not limited to panic disorder. <jats:italic>Hum Brain Mapp 36:3950\u20133958, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22889","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T05:25:15Z","timestamp":1436160315000},"page":"3950-3958","source":"Crossref","is-referenced-by-count":37,"title":["A neural mediator of human anxiety sensitivity"],"prefix":"10.1002","volume":"36","author":[{"given":"Ben J.","family":"Harrison","sequence":"first","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry The University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel A.","family":"Fullana","sequence":"additional","affiliation":[{"name":"Institute of Neuropsychiatry and Addictions, Hospital Del Mar CIBERSAM G21 Barcelona Spain"},{"name":"Department of Psychiatry Autonomous University of Barcelona Barcelona Spain"},{"name":"Hospital Del Mar Medical Research Institute (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Soriano\u2010Mas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bellvitge University Hospital\u2010IDIBELL CIBERSAM G17 Barcelona Spain"},{"name":"Department of Psychobiology and Methodology of Health Sciences Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Via","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bellvitge University Hospital\u2010IDIBELL CIBERSAM G17 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Pujol","sequence":"additional","affiliation":[{"name":"MRI Research Unit, CRC Mar, Hospital Del Mar CIBERSAM G21 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mart\u00ednez\u2010Zalaca\u00edn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Bellvitge University Hospital\u2010IDIBELL CIBERSAM G17 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Tinoco\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Autonomous University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-3852","authenticated-orcid":false,"given":"Christopher G.","family":"Davey","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry The University of Melbourne Victoria Australia"},{"name":"Orygen Youth Health Research Centre, Centre for Youth Mental Health The University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"L\u00f3pez\u2010Sol\u00e0","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience. 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