{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:24Z","timestamp":1786977804414,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002889","name":"Foundation for Prader-Willi Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002889","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Child Health Research Institute at Stanford University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Individuals with Prader\u2013Willi syndrome (PWS), a genetic disorder caused by mutations to the q11\u201013 region on chromosome 15, commonly show severe skin\u2010picking behaviors that can cause open wounds and sores on the body. To our knowledge, however, no studies have examined the potential neural mechanisms underlying these behaviors. Seventeen individuals with PWS, aged 6\u201325 years, who showed severe skin\u2010picking behaviors, were recruited and scanned on a 3T scanner. We used functional magnetic resonance imaging (fMRI) while episodes of skin picking were recorded on an MRI\u2010safe video camera. Three participants displayed skin picking continuously throughout the scan, three participants did not display skin picking, and the data for one participant evidenced significant B0 inhomogeneity that could not be corrected. The data for the remaining 10 participants (six male, four female) who displayed a sufficient number of picking and nonpicking episodes were subjected to fMRI analysis. Results showed that regions involved in interoceptive, motor, attention, and somatosensory processing were activated during episodes of skin\u2010picking behavior compared with nonpicking episodes. Scores obtained on the Self\u2010Injury Trauma scale were significantly negatively correlated with mean activation within the right insula and left precentral gyrus. These data indicate that itch and pain processes appear to underlie skin\u2010picking behaviors in PWS, suggesting that interoceptive disturbance may contribute to the severity and maintenance of abnormal skin\u2010picking behaviors in PWS. Implications for treatments are discussed.\n                    <jats:italic>Hum Brain Mapp 36:4135\u20134143, 2015<\/jats:italic>\n                    . \u00a9\n                    <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/hbm.22903","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T12:21:55Z","timestamp":1436876515000},"page":"4135-4143","source":"Crossref","is-referenced-by-count":30,"title":["Neural correlates of self\u2010injurious behavior in Prader\u2013Willi syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"Megan","family":"Klabunde","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Center for Interdisciplinary Brain Sciences Research Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Saggar","sequence":"additional","affiliation":[{"name":"Department of 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