{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:57:48Z","timestamp":1791050268058,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Marie Curie FP7 International Outgoing Fellowship","award":["628812"],"award-info":[{"award-number":["628812"]}]},{"name":"The donors of [Alzheimer's Disease Research], a program of BrightFocus Foundation"},{"name":"National Institute on Aging grants","award":["R01-AG045611"],"award-info":[{"award-number":["R01-AG045611"]}]},{"name":"National Institute on Aging grants","award":["P01-AG1792403"],"award-info":[{"award-number":["P01-AG1792403"]}]},{"name":"National Institute on Aging grants","award":["P50-AG023501"],"award-info":[{"award-number":["P50-AG023501"]}]},{"name":"National Institute on Aging grants","award":["R01-AG034570"],"award-info":[{"award-number":["R01-AG034570"]}]},{"name":"Tau Consortium"},{"name":"Consortium for Frontotemporal Dementia Research"},{"name":"John Douglas French Alzheimer's Foundation"},{"name":"State of California Department of Health Services Alzheimer's Disease Research Centre of California","award":["04-33516"],"award-info":[{"award-number":["04-33516"]}]},{"name":"Netherlands Initiative Brain and Cognition (NIHC), a part of the Netherlands Organization for Scientific Research (NWO)","award":["056-13-001"],"award-info":[{"award-number":["056-13-001"]}]},{"name":"Alzheimer Nederland and Stichting VUMC funds and Stichting Dioraphte"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest neurodegenerative changes associated with each variant has implications for early diagnosis, and for understanding the mechanisms that underlie regional vulnerability and disease progression in AD. We performed voxel\u2010based morphometry to detect atrophy patterns in early clinical stages of four AD phenotypes: Posterior cortical atrophy (PCA, \u201cvisual variant,\u201d\n                    <jats:italic>n =<\/jats:italic>\n                    93), logopenic variant primary progressive aphasia (lvPPA, \u201clanguage variant,\u201d\n                    <jats:italic>n =<\/jats:italic>\n                    74), and memory\u2010predominant AD categorized as early age\u2010of\u2010onset (EOAD, &lt;65 years,\n                    <jats:italic>n =<\/jats:italic>\n                    114) and late age\u2010of\u2010onset (LOAD, &gt;65 years,\n                    <jats:italic>n =<\/jats:italic>\n                    114). Patients with each syndrome were stratified based on: (1) degree of functional impairment, as measured by the clinical dementia rating (CDR) scale, and (2) overall extent of brain atrophy, as measured by a neuroimaging approach that sums the number of brain voxels showing significantly lower gray matter volume than cognitively normal controls (\n                    <jats:italic>n =<\/jats:italic>\n                    80). Even at the earliest clinical stage (CDR\u2009=\u20090.5 or bottom quartile of overall atrophy), patients with each syndrome showed both common and variant\u2010specific atrophy. Common atrophy across variants was found in temporoparietal regions that comprise the posterior default mode network (DMN). Early syndrome\u2010specific atrophy mirrored functional brain networks underlying functions that are uniquely affected in each variant: Language network in lvPPA, posterior cingulate cortex\u2010hippocampal circuit in amnestic EOAD and LOAD, and visual networks in PCA. At more advanced stages, atrophy patterns largely converged across AD variants. These findings support a model in which neurodegeneration selectively targets both the DMN and syndrome\u2010specific vulnerable networks at the earliest clinical stages of AD.\n                    <jats:italic>Hum Brain Mapp 36:4421\u20134437, 2015<\/jats:italic>\n                    . \u00a9\n                    <jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/hbm.22927","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T06:45:25Z","timestamp":1439275525000},"page":"4421-4437","source":"Crossref","is-referenced-by-count":235,"title":["Atrophy patterns in early clinical stages across distinct phenotypes of\n                    <scp>A<\/scp>\n                    lzheimer's disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Rik","family":"Ossenkoppele","sequence":"first","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"},{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"},{"name":"Department of Neurology &amp; Alzheimer Center Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan I.","family":"Cohn\u2010Sheehy","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"La Joie","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob W.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Alzheimer Center Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"},{"name":"Dementia Research Centre, UCL Institute of Neurology, University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.M.","family":"van Berckel","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A.","family":"Pijnenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Alzheimer Center Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Gorno\u2010Tempini","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Alzheimer Center Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Epidemiology &amp; Biostatistics VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Alzheimer Center Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California San Francisco San Francisco California"},{"name":"Helen Wills Neuroscience Institute, University of California Berkeley Berkeley California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102995"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm213"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31824b211b"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2013.860176"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122059"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70289-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl377"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.216"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.786"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1337"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2205-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.136"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2170-12.2012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5626-10.2011"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt162"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.09.225"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws327"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221536110"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305858"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062471"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905314106"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.037"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058331"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512454711"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c0d427"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt242"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.02.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.025"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu064"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2102-3"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.07.003"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0889"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000432"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24321"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317507308779"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21451"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp326"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.040"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140290.80962.BF"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825dce28"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.34"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000824"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.12.008"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.38"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2482070938"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111934"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2005.11.002"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt266"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1654"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203593109"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70306-9"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211001013"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.198"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.004"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132561"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22927","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:37:45Z","timestamp":1696581465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,11]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/hbm.22927"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22927","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,11]]}}}