{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:32:29Z","timestamp":1790429549559,"version":"4.1.0"},"reference-count":100,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34 MH089299-01"],"award-info":[{"award-number":["R34 MH089299-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32NS048004-08"],"award-info":[{"award-number":["5T32NS048004-08"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-1-0081"],"award-info":[{"award-number":["W81XWH-12-1-0081"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the neurofibromin 1 gene at locus 17q11.2. Individuals with NF1 have an increased incidence of learning disabilities, attention deficits, and autism spectrum disorders. As a single\u2010gene disorder, NF1 represents a valuable model for understanding gene\u2013brain\u2013behavior relationships. While mouse models have elucidated molecular and cellular mechanisms underlying learning deficits associated with this mutation, little is known about functional brain architecture in human subjects with NF1. To address this question, we used resting state functional connectivity magnetic resonance imaging (rs\u2010fcMRI) to elucidate the intrinsic network structure of 30 NF1 participants compared with 30 healthy demographically matched controls during an eyes\u2010open rs\u2010fcMRI scan. Novel statistical methods were employed to quantify differences in local connectivity (edge strength) and modularity structure, in combination with traditional global graph theory applications. Our findings suggest that individuals with NF1 have reduced anterior\u2013posterior connectivity, weaker bilateral edges, and altered modularity clustering relative to healthy controls. Further, edge strength and modular clustering indices were correlated with IQ and internalizing symptoms. These findings suggest that Ras signaling disruption may lead to abnormal functional brain connectivity; further investigation into the functional consequences of these alterations in both humans and in animal models is warranted. <jats:italic>Hum Brain Mapp 36:4566\u20134581, 2015<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.22937","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T05:29:15Z","timestamp":1440480555000},"page":"4566-4581","source":"Crossref","is-referenced-by-count":39,"title":["Resting state functional <scp>MRI<\/scp> reveals abnormal network connectivity in neurofibromatosis 1"],"prefix":"10.1002","volume":"36","author":[{"given":"Steffie N.","family":"Tomson","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, UCLA Los Angeles, California"},{"name":"Brain Mapping Center, UCLA Los Angeles, California"},{"name":"Center for Cognitive Neuroscience, UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, UCLA Los Angeles, California"},{"name":"Interdepartmental Neuroscience Program UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Rice University Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tena","family":"Rosser","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles Los Angeles, California"},{"name":"USC Keck School of Medicine Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Enrique","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience, UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alcino J.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, UCLA Los Angeles, California"},{"name":"Department of Neurobiology UCLA Los Angeles, California"},{"name":"Department of Psychology UCLA Los Angeles, California"},{"name":"Integrative Center for Learning and Memory, UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevera I.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Rice University Houston, Texas"},{"name":"Department of Statistics Rice University Houston, Texas"},{"name":"Jan and Dan Duncan Neurological Research Institute Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Y.","family":"Bookheimer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, UCLA Los Angeles, California"},{"name":"Center for Cognitive Neuroscience, UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Bearden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, UCLA Los Angeles, California"},{"name":"Department of Psychology UCLA Los Angeles, California"},{"name":"Integrative Center for Learning and Memory, UCLA Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Manual for the Child Behavior Checklist\/2\u20103 and 1992 Profile","author":"Achenbach T","year":"1992"},{"key":"e_1_2_5_3_1","volume-title":"Young Adult Self Report","author":"Achenbach T","year":"1997"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101951"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.05.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107130"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018985108"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180110701"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2003.07.008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3214"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.061"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90253-B"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.03.009"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20364"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature711"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.3.337"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2346223"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.060"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000032370.68306.8A"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90270-N"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00430"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.31887\/DCNS.2012.14.3\/gdichter","article-title":"Functional magnetic resonance imaging of autism spectrum disorders","volume":"14","author":"Dichter GS","year":"2012","journal-title":"Dialogues Clin Neurosci"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00783.2009"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.195.3.7754001"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22161"},{"key":"e_1_2_5_31_1","first-page":"190","article-title":"MR imaging of the corpus callosum in pediatric patients with neurofibromatosis type 1","volume":"22","author":"Dubovsky EC","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0036"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.2.r01ap25354"},{"key":"e_1_2_5_34_1","unstructured":"FirstMB SpitzerRL GibbonM WilliamsJBW(1997): Structured Clinical Interview for DSM\u2010IV\u00aeAxis I Disorders (SCID\u2010I) Clinician Version Scoresheet."},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.087"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<1::AID-AJMG3>3.0.CO;2-8"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxm045"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1868"},{"key":"e_1_2_5_39_1","volume-title":"Permutation, parametric, and bootstrap tests of hypotheses","author":"Good P","year":"2005"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470937273"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088297"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1904"},{"key":"e_1_2_5_43_1","first-page":"2330","volume-title":"Sparse Inverse Covariance Matrix Estimation Using Quadratic Approximation","author":"Hsieh C","year":"2011"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000179303.72345.ce"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01268.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047854"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:2<117::AID-MRDD5>3.0.CO;2-X"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1957110"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532802"},{"key":"e_1_2_5_50_1","first-page":"363","article-title":"Spatial regularization of functional connectivity using high\u2010dimensional Markov random fields","volume":"13","author":"Liu W","year":"2010","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003712"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0334"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0333-10.2010"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0323-1"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00605"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.08.011"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2010.00740.x"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.914"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq296"},{"key":"e_1_2_5_60_1","doi-asserted-by":"crossref","unstructured":"NarayanM AllenGI(2013): Randomized Approach to Differential Inference in Multi\u2010Subject Functional Connectivity. Proc 3rd Int Work Pattern Recognit Neuroimaging.","DOI":"10.1109\/PRNI.2013.29"},{"key":"e_1_2_5_61_1","unstructured":"NarayanM AllenGI TomsonSN(2015): Two sample inference for populations of graphical models with applications to functional brain connectivity. Submitted."},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601602103"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200022)97:2<119::AID-AJMG3>3.0.CO;2-3"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.027"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.179630"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.07.011"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809350723"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.054"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.047"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt333"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004829107"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.063"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00346"},{"key":"e_1_2_5_77_1","first-page":"e1000157","article-title":"Development of large\u2010scale functional brain networks in children","volume":"7","author":"Supekar K","year":"2009","journal-title":"Development"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.127"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2010.00117"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000162406.71300.b7"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5131-12.2013"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00639.x"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3539-11.2011"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0921"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12187"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22424"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038785"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-5-3"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90252-A"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.11.2.906"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss053"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2134734"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.034"},{"key":"e_1_2_5_95_1","volume-title":"Weschler Abbreviated Scale of Intelligence","author":"WASI","year":"1999"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.005"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2005"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_5_100_1","first-page":"773","article-title":"Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1","volume":"28","author":"Zamboni SL","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003109107"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.22937","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.22937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:36:18Z","timestamp":1696595778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.22937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":100,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/hbm.22937"],"URL":"https:\/\/doi.org\/10.1002\/hbm.22937","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}