{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:11:28Z","timestamp":1791911488682,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EI 816\/4\u20101 and LA 3071\/3\u20101"],"award-info":[{"award-number":["EI 816\/4\u20101 and LA 3071\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01\u2010MH074457"],"award-info":[{"award-number":["R01\u2010MH074457"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dystonia is characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements or postures. Functional neuroimaging studies have yielded abnormal task\u2010related sensorimotor activation in dystonia, but the results appear to be rather variable across studies. Further, study size was usually small including different types of dystonia. Here we performed an activation likelihood estimation (ALE) meta\u2010analysis of functional neuroimaging studies in patients with primary dystonia to test for convergence of dystonia\u2010related alterations in task\u2010related activity across studies. Activation likelihood estimates were based on previously reported regional maxima of task\u2010related increases or decreases in dystonia patients compared to healthy controls. The meta\u2010analyses encompassed data from 179 patients with dystonia reported in 18 functional neuroimaging studies using a range of sensorimotor tasks. Patients with dystonia showed bilateral increases in task\u2010related activation in the parietal operculum and ventral postcentral gyrus as well as right middle temporal gyrus. Decreases in task\u2010related activation converged in left supplementary motor area and left postcentral gyrus, right superior temporal gyrus and dorsal midbrain. Apart from the midbrain cluster, all between\u2010group differences in task\u2010related activity were retrieved in a sub\u2010analysis including only the 14 studies on patients with focal dystonia. For focal dystonia, an additional cluster of increased sensorimotor activation emerged in the caudal cingulate motor zone. The results show that dystonia is consistently associated with abnormal somatosensory processing in the primary and secondary somatosensory cortex along with abnormal sensorimotor activation of mesial premotor and right lateral temporal cortex. <jats:italic>Hum Brain Mapp 37:547\u2013557, 2016<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23050","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T13:14:46Z","timestamp":1447074886000},"page":"547-557","source":"Crossref","is-referenced-by-count":29,"title":["Altered sensorimotor activation patterns in idiopathic dystonia\u2014an activation likelihood estimation meta\u2010analysis of functional brain imaging studies"],"prefix":"10.1002","volume":"37","author":[{"given":"Annemette","family":"L\u00f8kkegaard","sequence":"first","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital Bispebjerg Copenhagen Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian M.","family":"Herz","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital Bispebjerg Copenhagen Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian N.","family":"Haagensen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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