{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:54:00Z","timestamp":1778590440720,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) funded by the Korean Government (MSIP)","award":["2015R1A5A7037676"],"award-info":[{"award-number":["2015R1A5A7037676"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neocortical phenotype of cortical surface area (CSA) and thickness (CT) are influenced by distinctive genetic factors and undergo differential developmental trajectories, which could be captured using the individualized cortical structural covariance (ISC). Disturbed patterns of neocortical development and maturation underlie the perceptual disturbance of psychosis including auditory hallucination (AH). To demonstrate the utility of selected ISC features as primal biomarker of AH in first\u2010episode psychosis (FEP) subjects experiencing AH (FEP\u2010AH), we employed herein a support vector machine (SVM). A total of 147 subjects (FEP\u2010AH, <jats:italic>n =<\/jats:italic> 27; FEP\u2010NAH, <jats:italic>n =<\/jats:italic> 24; HC, <jats:italic>n =<\/jats:italic> 96) underwent <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted magnetic resonance imaging at 3T. The FreeSurfer software suite was used for cortical parcellation, with the CSA\u2010ISC and CT\u2010ISC then calculated. The most informative ISCs showing statistical significance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) across every run of leave\u2010one\u2010out group\u2010comparison were aligned according to the absolute value of averaged t\u2010statistics and were packaged into candidate feature sets for classification analysis using the SVM. An optimal feature set comprising three CSA\u2010ISCs, including the intraparietal sulcus, Broca's complex, and the anterior insula, distinguished FEP\u2010AH from FEP\u2010NAH subjects with 83.6% accuracy (sensitivity\u2009=\u200982.8%; specificity\u2009=\u200985.7%). Furthermore, six CT\u2010ISCs encompassing the executive control network and Wernicke's module classified FEP\u2010AH from FEP\u2010NAH subjects with 82.3% accuracy (sensitivity\u2009=\u200979.5%; specificity\u2009=\u200988.6%). Finally, extended sets of ISCs related to the default\u2010mode network distinguished FEP\u2010AH or FEP\u2010NAH from HC subjects with 89.0\u201393.0% accuracy (sensitivity\u2009=\u200988.4\u201393.4%; specificity\u2009=\u200989.0\u201394.1%). This study established a distinctive intermediate phenotype of biological proneness for AH in FEP using CSA\u2010ISCs as well as a state marker of disease progression using CT\u2010ISCs. <jats:italic>Hum Brain Mapp 37:1051\u20131065, 2016<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23083","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T15:39:58Z","timestamp":1450366798000},"page":"1051-1065","source":"Crossref","is-referenced-by-count":32,"title":["Individualized covariance profile of cortical morphology for auditory hallucinations in first\u2010episode psychosis"],"prefix":"10.1002","volume":"37","author":[{"given":"Je\u2010Yeon","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung","family":"Nyun Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Young Lee","sequence":"additional","affiliation":[{"name":"SNU\u2010MRC Institute of Human Behavioral Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myong\u2010Wuk","family":"Chon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Soo Kwon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"SNU\u2010MRC Institute of Human Behavioral Medicine Seoul Republic of Korea"},{"name":"Department of Brain and Cognitive Sciences College of Natural Science, Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3465"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3554-12.2013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011616107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/17.1.27"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu080"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt172"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(94)90110-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.140"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311772110"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010109"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.053"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0519-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs128"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.04.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr013"},{"issue":"4","key":"e_1_2_6_23_1","first-page":"S305","article-title":"From tones in tinnitus to sensed social interaction in schizophrenia: How understanding cortical organization can inform the study of hallucinations and psychosis. 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