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However, intrinsic functional connectivity (iFC) between amygdala and these networks has rarely been examined in relation to anxiety, especially across the lifespan. We employed resting\u2010state functional MRI data from 280 healthy adults (18\u201383.5 yrs) to elucidate the relationship between anxiety and amygdala iFC with common cortical networks including the visual network, somatomotor network, dorsal attention network, ventral attention network, limbic network, frontoparietal network, and default network. Global and network\u2010specific iFC were separately computed as mean iFC of amygdala with the entire cerebral cortex and each cortical network. We detected negative correlation between global positive amygdala iFC and trait anxiety. Network\u2010specific associations between amygdala iFC and anxiety were also detectable. Specifically, the higher iFC strength between the left amygdala and the limbic network predicted lower state anxiety. For the trait anxiety, left amygdala anxiety\u2013connectivity correlation was observed in both somatomotor and dorsal attention networks, whereas the right amygdala anxiety\u2013connectivity correlation was primarily distributed in the frontoparietal and ventral attention networks. Ventral attention network exhibited significant anxiety\u2013gender interactions on its iFC with amygdala. Together with findings from additional vertex\u2010wise analysis, these data clearly indicated that both low\u2010level sensory networks and high\u2010level associative networks could contribute to detectable predictions of anxiety behaviors by their iFC profiles with the amygdala. This set of systems neuroscience findings could lead to novel functional network models on neural correlates of human anxiety and provide targets for novel treatment strategies on anxiety disorders. <jats:italic>Hum Brain Mapp 37:1178\u20131193, 2016<\/jats:italic>. \u00a9 <jats:bold>2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23094","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T09:46:44Z","timestamp":1450691204000},"page":"1178-1193","source":"Crossref","is-referenced-by-count":63,"title":["Lifespan anxiety is reflected in human amygdala cortical connectivity"],"prefix":"10.1002","volume":"37","author":[{"given":"Ye","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center Institute of Psychology, Chinese Academy of Sciences Beijing 100101 China"},{"name":"Laboratory for Functional 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