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Here, we tested whether in patients with PD under dopaminergic treatment functional connectivity of the STN differs from healthy controls (HC) and whether some brain regions show (anti\u2010) correlations between functional connectivity with STN and motor symptoms. We used functional magnetic resonance imaging to investigate whole\u2010brain resting\u2010state functional connectivity with STN in 54 patients with PD and 55 HC matched for age, gender, and within\u2010scanner motion. Compared to HC, we found attenuated negative STN\u2010coupling with Crus I of the right cerebellum and with right ventromedial prefrontal regions in patients with PD. Furthermore, we observed enhanced negative STN\u2010coupling with bilateral intraparietal sulcus\/superior parietal cortex, right sensorimotor, right premotor, and left visual cortex compared to HC. Finally, we found a decline in positive STN\u2010coupling with the left insula related to severity of motor symptoms and a decline of inter\u2010hemispheric functional connectivity between left and right STN with progression of PD\u2010related motor symptoms. Motor symptom related uncoupling of the insula, a key region in the saliency network and for executive function, from the STN might be associated with well\u2010known executive dysfunction in PD. Moreover, uncoupling between insula and STN might also induce an insufficient setting of thresholds for the discrimination between relevant and irrelevant salient environmental stimuli, explaining observations of disturbed response control in PD. In sum, motor symptoms in PD are associated with a reduced coupling between STN and a key region for executive function. <jats:italic>Hum Brain Mapp 37:1235\u20131253, 2016<\/jats:italic>. \u00a9 <jats:bold>2015 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23099","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T08:04:48Z","timestamp":1450944288000},"page":"1235-1253","source":"Crossref","is-referenced-by-count":24,"title":["Functional Connectivity Differences of the Subthalamic Nucleus Related to <scp>P<\/scp>arkinson's Disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Christian","family":"Mathys","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Medical Faculty, University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Caspers","sequence":"additional","affiliation":[{"name":"Department of 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