{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:32:19Z","timestamp":1790789539455,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006290","name":"Institute of Management Accountants","doi-asserted-by":"publisher","award":["204\/GR\u20102009\u20101606835; RC 10\u201011\u201012\u201013\/A and in part by the NIH National Institute of Neurological Disorders and Stroke award R01 NS074980 (DWS)."],"award-info":[{"award-number":["204\/GR\u20102009\u20101606835; RC 10\u201011\u201012\u201013\/A and in part by the NIH National Institute of Neurological Disorders and Stroke award R01 NS074980 (DWS)."]}],"id":[{"id":"10.13039\/100006290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    White matter abnormalities have been shown in the large deep fibers of Alzheimer's disease patients. However, the late myelinating superficial white matter comprised of intracortical myelin and short\u2010range association fibers has not received much attention. To investigate this area, we extracted a surface corresponding to the superficial white matter beneath the cortex and then applied a cortical pattern\u2010matching approach which allowed us to register and subsequently sample diffusivity along thousands of points at the interface between the gray matter and white matter in 44 patients with Alzheimer's disease (Age: 71.02\u2009\u00b1\u20095.84, 16M\/28F) and 47 healthy controls (Age 69.23\u2009\u00b1\u20094.45, 19M\/28F). In patients we found an overall increase in the axial and radial diffusivity across most of the superficial white matter (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) with increases in diffusivity of more than 20% in the bilateral parahippocampal regions and the temporal and frontal lobes. Furthermore, diffusivity correlated with the cognitive deficits measured by the Mini\u2010Mental State Examination scores (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). The superficial white matter has a unique microstructure and is critical for the integration of multimodal information during brain maturation and aging. Here we show that there are major abnormalities in patients and the deterioration of these fibers relates to clinical symptoms in Alzheimer's disease.\n                    <jats:italic>Hum Brain Mapp 37:1321\u20101334, 2016<\/jats:italic>\n                    . \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hbm.23105","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T08:02:42Z","timestamp":1453536162000},"page":"1321-1334","source":"Crossref","is-referenced-by-count":80,"title":["The superficial white matter in Alzheimer's disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Owen R","family":"Phillips","sequence":"first","affiliation":[{"name":"Morphology and Morphometry for NeuroImaging Lab, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"},{"name":"Neuroscience Dept. University of Rome \u201cTor Vergata\u201d Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu H.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Ahmanson Lovelace Brain Mapping Center Neurology Dept. UCLA  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Piras","sequence":"additional","affiliation":[{"name":"Museo Storico della Fisica e Centro di Studi e Ricerche \u201cEnrico Fermi\u201d Rome Italy"},{"name":"Neuropsychiatry Laboratory, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Donata","family":"Orfei","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Laboratory, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Iorio","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Laboratory, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Narr","sequence":"additional","affiliation":[{"name":"Ahmanson Lovelace Brain Mapping Center Neurology Dept. UCLA  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Shattuck","sequence":"additional","affiliation":[{"name":"Ahmanson Lovelace Brain Mapping Center Neurology Dept. UCLA  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caltagirone","sequence":"additional","affiliation":[{"name":"Neuroscience Dept. University of Rome \u201cTor Vergata\u201d Italy"},{"name":"Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Spalletta","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Laboratory, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Morphology and Morphometry for NeuroImaging Lab, Clinical and Behavioural Neurology Dept. IRCCS Santa Lucia Foundation Rome Italy"},{"name":"Human Studies Dept. LUMSA University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.02.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22837"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.050"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294607"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014168"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000215)59:4<477::AID-JNR2>3.0.CO;2-J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2007.11.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.09.062"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.050"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d7d8cb"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0283-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini\u2010mental state","author":"Folstein MF","year":"1975","journal-title":"J Psychiatric Res."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.05.015.2009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-140468","article-title":"A theta\u2010band EEG based index for early diagnosis of Alzheimer's disease","author":"Gallego\u2010Jutgl\u00e0 E","year":"2014","journal-title":"J Alzheimers Dis."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090307"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2811-13.2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22716"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282f0d40c"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9624-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.001"},{"key":"e_1_2_7_26_1","article-title":"White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI","author":"Jones DK","year":"2012","journal-title":"Neuroimage"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","unstructured":"JoshiA ShattuckDW LeahyRM(2012): A Fast and Accurate Method forAutomated Cortical Surface Registration and Labeling. 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