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Few studies have taken a whole\u2010brain perspective in the functional connectivity (FC) analysis of these two disorders in resting state. It limits the ability to identify regionally and psychopathologically specific network abnormalities with their subsequent use as diagnostic marker and novel treatment strategy. The whole brain FC using a novel FC metric was compared, that is, scaled correlation, which they demonstrated to be a reliable FC statistics, but have higher statistical power in two\u2010sample\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test of whole brain FC analysis. About 21 GAD and 18 PD patients were compared with 22 matched control subjects during resting\u2010state, respectively. It was found that GAD patients demonstrated increased FC between hippocampus\/parahippocampus and fusiform gyrus among the most significantly changed FC, while PD was mainly associated with greater FC between somatosensory cortex and thalamus. Besides such regional specificity, it was observed that psychopathological specificity in that the disrupted FC pattern in PD and GAD correlated with their respective symptom severity. The findings suggested that the increased FC between hippocampus\/parahippocampus and fusiform gyrus in GAD were mainly associated with a fear generalization related neural circuit, while the greater FC between somatosensory cortex and thalamus in PD were more likely linked to interoceptive processing. Due to the observed regional and psychopathological specificity, their findings bear important clinical implications for the potential treatment strategy.\n                    <jats:italic>Hum Brain Mapp 37:1459\u20101473, 2016<\/jats:italic>\n                    . \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hbm.23113","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T08:12:53Z","timestamp":1453536773000},"page":"1459-1473","source":"Crossref","is-referenced-by-count":117,"title":["Differential alterations of resting\u2010state functional connectivity in generalized anxiety disorder and panic disorder"],"prefix":"10.1002","volume":"37","author":[{"given":"Huiru","family":"Cui","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of 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