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This is why the present functional magnetic resonance imaging (fMRI) study investigated immediate disorder\u2010related threat processing in 30 SAD patients and 30 healthy controls (HC) with a novel, standardized set of highly ecologically valid, disorder\u2010related complex visual scenes. SAD patients rated disorder\u2010related as compared with neutral scenes as more unpleasant, arousing and anxiety\u2010inducing than HC. On the neural level, disorder\u2010related as compared with neutral scenes evoked differential responses in SAD patients in a widespread emotion processing network including (para\u2010)limbic structures (e.g. amygdala, insula, thalamus, globus pallidus) and cortical regions (e.g. dorsomedial prefrontal cortex (dmPFC), posterior cingulate cortex (PCC), and precuneus). Functional connectivity analysis yielded an altered interplay between PCC\/precuneus and paralimbic (insula) as well as cortical regions (dmPFC, precuneus) in SAD patients, which emphasizes a central role for PCC\/precuneus in disorder\u2010related scene processing. Hyperconnectivity of globus pallidus with amygdala, anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) additionally underlines the relevance of this region in socially anxious threat processing. Our findings stress the importance of specific disorder\u2010related stimuli for the investigation of altered emotion processing in SAD. Disorder\u2010related threat processing in SAD reveals anomalies at multiple stages of emotion processing which may be linked to increased anxiety and to dysfunctionally elevated levels of self\u2010referential processing reported in previous studies.\n                    <jats:italic>Hum Brain Mapp 37:1559\u20101572, 2016<\/jats:italic>\n                    . \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/hbm.23120","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T03:06:42Z","timestamp":1453691202000},"page":"1559-1572","source":"Crossref","is-referenced-by-count":56,"title":["Abnormal brain activation and connectivity to standardized disorder\u2010related visual scenes in social anxiety disorder"],"prefix":"10.1002","volume":"37","author":[{"given":"Carina Yvonne","family":"Heitmann","sequence":"first","affiliation":[{"name":"Institute of Medical Psychology and Systems Neuroscience, University of Muenster, 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