{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:33:35Z","timestamp":1791916415896,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01\u2010MH086517"],"award-info":[{"award-number":["R01\u2010MH086517"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["MH093679"],"award-info":[{"award-number":["MH093679"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR000048"],"award-info":[{"award-number":["KL2TR000048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ability to process and respond to emotional facial expressions is a critical skill for healthy social and emotional development. There has been growing interest in understanding the neural circuitry underlying development of emotional processing, with previous research implicating functional connectivity between amygdala and frontal regions. However, existing work has focused on threatening emotional faces, raising questions regarding the extent to which these developmental patterns are specific to threat or to emotional face processing more broadly. In the current study, we examined age\u2010related changes in brain activity and amygdala functional connectivity during an fMRI emotional face matching task (including angry, fearful, and happy faces) in 61 healthy subjects aged 7\u201325 years. We found age\u2010related decreases in ventral medial prefrontal cortex activity in response to happy faces but not to angry or fearful faces, and an age\u2010related change (shifting from positive to negative correlation) in amygdala\u2013anterior cingulate cortex\/medial prefrontal cortex (ACC\/mPFC) functional connectivity to all emotional faces. Specifically, positive correlations between amygdala and ACC\/mPFC in children changed to negative correlations in adults, which may suggest early emergence of bottom\u2010up amygdala excitatory signaling to ACC\/mPFC in children and later development of top\u2010down inhibitory control of ACC\/mPFC over amygdala in adults. Age\u2010related changes in amygdala\u2013ACC\/mPFC connectivity did not vary for processing of different facial emotions, suggesting changes in amygdala\u2013ACC\/mPFC connectivity may underlie development of broad emotional processing, rather than threat\u2010specific processing. <jats:italic>Hum Brain Mapp 37:1684\u20131695, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23129","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T06:22:50Z","timestamp":1456899770000},"page":"1684-1695","source":"Crossref","is-referenced-by-count":123,"title":["Age\u2010related changes in amygdala\u2013frontal connectivity during emotional face processing from childhood into young adulthood"],"prefix":"10.1002","volume":"37","author":[{"given":"Minjie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn","family":"Kujawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Psychology Stony Brook University Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa H.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Psychology Roosevelt University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heide","family":"Klumpp","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate D.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Monk","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Luan","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Psychology University of Illinois at Chicago Chicago Illinois"},{"name":"Department of Anatomy and Cell Biology University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03004430903059318"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199902000-00019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12090231"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2006.00480.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2009.06.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2012.05.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)7:1<38::AID-HBM4>3.0.CO;2-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5127\/jep.016611"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dr.2007.08.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr111"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8624.00533"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2006.12.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2005.15.563"},{"key":"e_1_2_6_17_1","first-page":"223","article-title":"Neural mechanisms of reading facial emotions in young and older adults","volume":"3","author":"Ebner NC","year":"2012","journal-title":"Emot Sci"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9507.2009.00572.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095457940300018X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0291"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3446-12.2013"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2513"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.073"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_6_27_1","first-page":"53","article-title":"Procedures for detecting outlying observations in samples","volume":"11","author":"Grubbs FE","year":"1974","journal-title":"Technometrics"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20114"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.01.023"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200001170-00009"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01786-9"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1179"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01652.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00316.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.003"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200102120-00047"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.025"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2554"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_6_41_1","unstructured":"MatthewB Jean\u2010LucA RomainV Jean\u2010BaptisteP.Region of interest analysis using an SPM toolbox [abstract] Presented at the 8th International Conference on Functional Mapping of the Human Brain June 2\u20136 2002 Sendai Japan."},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.068"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362328"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00355-0"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.03.010"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1242-09.2009"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp029"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2010.08.006"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5603-07.2008"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1087"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00168-9"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22014"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.065"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.063"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.2.200.989"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/13154"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.018"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01066-0"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2007.00614.x"},{"key":"e_1_2_6_63_1","first-page":"38","volume-title":"Emotion Regulation and Psychopathology: A Transdiagnostic Approach to Etiology and Treatment","author":"Thompson RA","year":"2009"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq007"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029431"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.044"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.072"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.010"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4317-12.2013"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20616"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.03.009"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:59:24Z","timestamp":1696611564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1002\/hbm.23129"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23129","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}