{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:22:19Z","timestamp":1768544539556,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are an increasing number of neuroimaging studies that allow a better understanding of symptoms, neural correlates and associated conditions of fibromyalgia. However, the results of these studies are difficult to compare, as they include a heterogeneous group of patients, use different stimulation paradigms, tasks, and the statistical evaluation of neuroimaging data shows high variability. Therefore, this meta\u2010analytic approach aimed at evaluating potential alterations in neuronal brain activity or structure related to pain processing in fibromyalgia syndrome (FMS) patients, using quantitative coordinate\u2010based \u201cactivation likelihood estimation\u201d (ALE) meta\u2010analysis. 37 FMS papers met the inclusion criteria for an ALE analysis (1,264 subjects, 274 activation foci). A pooled ALE analysis of different modalities of neuroimaging and additional analyses according functional and structural changes indicated differences between FMS patients and controls in the insula, amygdala, anterior\/mid cingulate cortex, superior temporal gyrus, the primary and secondary somatosensory cortex, and lingual gyrus. Our analysis showed consistent results across FMS studies with potential abnormalities especially in pain\u2010related brain areas. Given that similar alterations have already been demonstrated in patients with other chronic pain conditions and the lack of adequate control groups of chronic pain subjects in most FMS studies, it is not clear however, whether these findings are associated with chronic pain in general or are unique features of patients with FMS. <jats:italic>Hum Brain Mapp 37:1749\u20131758, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23132","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:09:53Z","timestamp":1455235793000},"page":"1749-1758","source":"Crossref","is-referenced-by-count":70,"title":["Coordinate\u2010based (ALE) meta\u2010analysis of brain activation in patients with fibromyalgia"],"prefix":"10.1002","volume":"37","author":[{"given":"Mahboobeh","family":"Dehghan","sequence":"first","affiliation":[{"name":"Department of Psychosomatics and Psychotherapy University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schmidt\u2010Wilcke","sequence":"additional","affiliation":[{"name":"Department of Neurology Berufsgenossenschaftliches Universit\u00e4tsklinikum Bergmannsheil, Ruhr Universit\u00e4t Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Pfleiderer","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon B.","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine (INM\u20101), Research Center J\u00fclich  Germany"},{"name":"Institute of Clinical Neuroscience and Medical Psychology, Heinrich\u2010Heine University D\u00fcsseldorf 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