{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:55:40Z","timestamp":1768910140042,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Brain Mapp."],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1002\/hbm.23165","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T06:25:13Z","timestamp":1457504713000},"page":"2173-2184","source":"Crossref","is-referenced-by-count":15,"title":["The cumulative effect of genetic polymorphisms on depression and brain structural integrity"],"prefix":"10.1002","volume":"37","author":[{"given":"Milutin","family":"Kostic","sequence":"first","affiliation":[{"name":"Institute of Mental Health; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Canu","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University; Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University; Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Munjiza","sequence":"additional","affiliation":[{"name":"Institute of Mental Health; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Novakovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Clinical Center of Serbia; Belgrade Serbia"},{"name":"School of Medicine; University of Belgrade; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerija","family":"Dobricic","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Clinical Center of Serbia; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Maria Ferraro","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University; Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Miler Jerkovic","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering; University of Belgrade; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Pekmezovic","sequence":"additional","affiliation":[{"name":"School of Medicine; University of Belgrade; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusica","family":"Lecic Tosevski","sequence":"additional","affiliation":[{"name":"Institute of Mental Health; Belgrade Serbia"},{"name":"School of Medicine; University of Belgrade; Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University; Milan Italy"},{"name":"Department of Neurology; Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University; Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"10.1002\/hbm.23165-BIB0001|hbm23165-cit-0001","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.psyneuen.2009.03.017","article-title":"Gene-environment interactions predict cortisol responses after acute stress: Implications for the etiology of depression","volume":"34","author":"Alexander","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1002\/hbm.23165-BIB0002|hbm23165-cit-0002","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.neubiorev.2013.06.006","article-title":"The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes","volume":"37","author":"Antypa","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1002\/hbm.23165-BIB0003|hbm23165-cit-0003","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0004|hbm23165-cit-0004","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0044|hbm23165-cit-0044","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/mp.2009.44","article-title":"Vulnerability genes or plasticity genes?","volume":"14","author":"J","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0005|hbm23165-cit-0005","doi-asserted-by":"crossref","first-page":"158746","DOI":"10.1155\/2013\/158746","article-title":"Psychomotor retardation in depression: A systematic review of diagnostic, pathophysiologic, and therapeutic implications","volume":"2013","author":"Bennabi","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1002\/hbm.23165-BIB0006|hbm23165-cit-0006","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00415-015-7701-z","article-title":"Brain structural abnormalities in patients with major depression with or without generalized anxiety disorder comorbidity","volume":"262","author":"Canu","year":"2015","journal-title":"J Neurol"},{"key":"10.1002\/hbm.23165-BIB0007|hbm23165-cit-0007","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"10.1002\/hbm.23165-BIB0008|hbm23165-cit-0008","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/nimg.2002.1136","article-title":"Virtual in vivo interactive dissection of white matter fasciculi in the human brain","volume":"17","author":"Catani","year":"2002","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0009|hbm23165-cit-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2011.01.003","article-title":"Reduction of dorsolateral prefrontal cortex gray matter in late-life depression","volume":"193","author":"Chang","year":"2011","journal-title":"Psychiatry Res"},{"key":"10.1002\/hbm.23165-BIB0010|hbm23165-cit-0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0011|hbm23165-cit-0011","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.mp.4000911","article-title":"MAO-A and COMT polymorphisms and gene effects in narcolepsy","volume":"6","author":"Dauvilliers","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0012|hbm23165-cit-0012","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0013|hbm23165-cit-0013","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.neuroimage.2012.02.039","article-title":"Catechol-O-methyltransferase gene variation: Impact on amygdala response to aversive stimuli","volume":"60","author":"Domschke","year":"2012","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0014|hbm23165-cit-0014","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000381456","article-title":"Diurnal variation of plasma brain-derived neurotrophic factor levels in women with functional hypothalamic amenorrhea","volume":"101","author":"Drakopoulos","year":"2015","journal-title":"Neuroendocrinology"},{"key":"10.1002\/hbm.23165-BIB0015|hbm23165-cit-0015","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I\/P)","author":"First","year":"2002"},{"key":"10.1002\/hbm.23165-BIB0016|hbm23165-cit-0016","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hbm.23165-BIB0017|hbm23165-cit-0017","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuroimage.2009.02.008","article-title":"High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding","volume":"46","author":"Frokjaer","year":"2009","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0018|hbm23165-cit-0018","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0019|hbm23165-cit-0019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","article-title":"Reduced prefrontal glutamate\/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy","volume":"64","author":"Hasler","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0020|hbm23165-cit-0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1741-7015-12-7","article-title":"Interaction between stress and the BDNF Val66Met polymorphism in depression: A systematic review and meta-analysis","volume":"12","author":"Hosang","year":"2014","journal-title":"BMC Med"},{"key":"10.1002\/hbm.23165-BIB0021|hbm23165-cit-0021","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/npp.2010.199","article-title":"White matter changes in healthy adolescents at familial risk for unipolar depression: A diffusion tensor imaging study","volume":"36","author":"Huang","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hbm.23165-BIB0022|hbm23165-cit-0022","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: A meta-analysis of resting-state functional connectivity","volume":"72","author":"Kaiser","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0023|hbm23165-cit-0023","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1192\/bjp.bp.108.052688","article-title":"Morphometric analysis of neuronal and glial cell pathology in the dorsolateral prefrontal cortex in late-life depression","volume":"195","author":"Khundakar","year":"2009","journal-title":"Br J Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0024|hbm23165-cit-0024","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jad.2009.04.023","article-title":"Major depressive disorder and white matter abnormalities: A diffusion tensor imaging study with tract-based spatial statistics","volume":"120","author":"Kieseppa","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1002\/hbm.23165-BIB0025|hbm23165-cit-0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1192\/bjp.bp.113.143529","article-title":"Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder","volume":"206","author":"Legge","year":"2015","journal-title":"Br J Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0026|hbm23165-cit-0026","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.biopsych.2009.10.027","article-title":"Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: Relevance to neuroimaging studies","volume":"67","author":"Maciag","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0027|hbm23165-cit-0027","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.biopsych.2009.10.006","article-title":"A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression","volume":"67","author":"Mannie","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0028|hbm23165-cit-0028","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/mp.2009.36","article-title":"Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis","volume":"15","author":"Mier","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0029|hbm23165-cit-0029","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","article-title":"An integrative theory of prefrontal cortex function","volume":"24","author":"Miller","year":"2001","journal-title":"Ann Rev Neurosci"},{"key":"10.1002\/hbm.23165-BIB0030|hbm23165-cit-0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neuroimage.2008.12.033","article-title":"A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes","volume":"45","author":"Morey","year":"2009","journal-title":"NeuroImage"},{"key":"10.1002\/hbm.23165-BIB0031|hbm23165-cit-0031","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-5380-1-3","article-title":"Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression","volume":"1","author":"Murphy","year":"2011","journal-title":"Biol Mood Anxiety Disord"},{"key":"10.1002\/hbm.23165-BIB0032|hbm23165-cit-0032","doi-asserted-by":"crossref","first-page":"e73290","DOI":"10.1371\/journal.pone.0073290","article-title":"Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory","volume":"8","author":"Opmeer","year":"2013","journal-title":"PloS one"},{"key":"10.1002\/hbm.23165-BIB0034|hbm23165-cit-0034","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/neu.2015.25","article-title":"Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression","volume":"27","author":"Phillips","year":"2015","journal-title":"Acta Neuropsychiatr"},{"key":"10.1002\/hbm.23165-BIB0035|hbm23165-cit-0035","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/npp.2009.104","article-title":"Neurocircuitry of mood disorders","volume":"35","author":"Price","year":"2010","journal-title":"Neuropsychopharmacology:"},{"key":"10.1002\/hbm.23165-BIB0036|hbm23165-cit-0036","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1523\/JNEUROSCI.3113-13.2014","article-title":"Additive gene-environment effects on hippocampal structure in healthy humans","volume":"34","author":"Rabl","year":"2014","journal-title":"J Neurosci"},{"key":"10.1002\/hbm.23165-BIB0037|hbm23165-cit-0037","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/sj.npp.1301234","article-title":"GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression","volume":"32","author":"Rajkowska","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hbm.23165-BIB0038|hbm23165-cit-0038","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/mrm.10677","article-title":"Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI","volume":"51","author":"Rohde","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1002\/hbm.23165-BIB0039|hbm23165-cit-0039","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archpsyc.56.11.1043","article-title":"Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy","volume":"56","author":"Sanacora","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/hbm.23165-BIB0040|hbm23165-cit-0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1212\/WNL.49.1.30","article-title":"An association between head circumference and Alzheimer's disease in a population-based study of aging and dementia","volume":"49","author":"Schofield","year":"1997","journal-title":"Neurology"},{"key":"10.1002\/hbm.23165-BIB0041|hbm23165-cit-0041","doi-asserted-by":"crossref","first-page":"53","DOI":"10.31887\/DCNS.2013.15.1\/esibille","article-title":"Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders","volume":"15","author":"Sibille","year":"2013","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1002\/hbm.23165-BIB0042|hbm23165-cit-0042","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1093\/hmg\/ddr358","article-title":"A generalizable hypothesis for the genetic architecture of disease: Pleomorphic risk loci","volume":"20","author":"Singleton","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1002\/hbm.23165-BIB0043|hbm23165-cit-0043","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/mp.2008.109","article-title":"Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicity","volume":"15","author":"Verhagen","year":"2010","journal-title":"Mol Psychiatry"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/hbm.23165\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T19:25:02Z","timestamp":1655234702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23165"}},"subtitle":["Multigene Effect and Brain Integrity in MDD"],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"URL":"https:\/\/doi.org\/10.1002\/hbm.23165","archive":["Portico"],"relation":{},"ISSN":["1065-9471"],"issn-type":[{"value":"1065-9471","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}