{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:57:07Z","timestamp":1771261027427,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"The National Key Basic Research and Development Program (973)","award":["2011CB707800"],"award-info":[{"award-number":["2011CB707800"]}]},{"name":"The Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB02030300"],"award-info":[{"award-number":["XDB02030300"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91132301"],"award-info":[{"award-number":["91132301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007333","name":"Alzheimer\u2019s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DOD ADNI (Department of Defense award)","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Brain Mapp."],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1002\/hbm.23183","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T05:56:40Z","timestamp":1459144600000},"page":"2419-2430","source":"Crossref","is-referenced-by-count":19,"title":["Impact of<i>PICALM<\/i>and<i>CLU<\/i>on hippocampal degeneration"],"prefix":"10.1002","volume":"37","author":[{"given":"Xianfeng","family":"Yang","sequence":"first","affiliation":[{"name":"The Queensland Brain Institute; The University of Queensland; Brisbane QLD 4072 Australia"},{"name":"The Centre for Advanced Imaging; The University of Queensland; Brisbane QLD 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Brain Science; Institute of Automation; Chinese Academy of Sciences; Beijing 100190 China"},{"name":"Brainnetome Center; Institute of Automation, Chinese Academy of Science; Beijing 100190 China"},{"name":"National Laboratory of Pattern Recognition; Institute of Automation; Chinese Academy of Science; Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Brain Science; Institute of Automation; Chinese Academy of Sciences; Beijing 100190 China"},{"name":"Brainnetome Center; Institute of Automation, Chinese Academy of Science; Beijing 100190 China"},{"name":"National Laboratory of Pattern Recognition; Institute of Automation; Chinese Academy of Science; Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghui","family":"Li","sequence":"additional","affiliation":[{"name":"The Queensland Brain Institute; The University of Queensland; Brisbane QLD 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzi","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Queensland Brain Institute; The University of Queensland; Brisbane QLD 4072 Australia"},{"name":"The Centre for Advanced Imaging; The University of Queensland; Brisbane QLD 4072 Australia"},{"name":"CAS Center for Excellence in Brain Science; Institute of Automation; Chinese Academy of Sciences; Beijing 100190 China"},{"name":"Brainnetome Center; Institute of Automation, Chinese Academy of Science; Beijing 100190 China"},{"name":"National Laboratory of Pattern Recognition; Institute of Automation; Chinese Academy of Science; Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"10.1002\/hbm.23183-BIB0001|hbm23183-cit-0001","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0169-328X(95)00097-C","article-title":"Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease","volume":"33","author":"Bertrand","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1002\/hbm.23183-BIB0002|hbm23183-cit-0002","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archneurol.2010.108","article-title":"Genetic variation and neuroimaging measures in Alzheimer disease","volume":"67","author":"Biffi","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1002\/hbm.23183-BIB0003|hbm23183-cit-0003","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1176\/appi.ajp.2011.10101509","article-title":"Association of the Alzheimer's gene SORL1 with hippocampal volume in young, healthy adults","volume":"168","author":"Bralten","year":"2011","journal-title":"Am J Psychiatry"},{"key":"10.1002\/hbm.23183-BIB0004|hbm23183-cit-0004","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archneurol.2010.147","article-title":"Replication of CLU, CR1, and PICALM associations with Alzheimer disease","volume":"67","author":"Carrasquillo","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1002\/hbm.23183-BIB0005|hbm23183-cit-0005","doi-asserted-by":"crossref","first-page":"210 e1","DOI":"10.1016\/j.neurobiolaging.2011.09.016","article-title":"Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population","volume":"33","author":"Chen","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1002\/hbm.23183-BIB0006|hbm23183-cit-0006","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1109\/42.650882","article-title":"Volumetric transformation of brain anatomy","volume":"16","author":"Christensen","year":"1997","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1002\/hbm.23183-BIB0007|hbm23183-cit-0007","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2008.02.003","article-title":"Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo","volume":"58","author":"Cirrito","year":"2008","journal-title":"Neuron"},{"key":"10.1002\/hbm.23183-BIB0008|hbm23183-cit-0008","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1093\/hmg\/ddq221","article-title":"Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals","volume":"19","author":"Corneveaux","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1002\/hbm.23183-BIB0009|hbm23183-cit-0009","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0896-6273(03)00850-X","article-title":"ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo","volume":"41","author":"DeMattos","year":"2004","journal-title":"Neuron"},{"key":"10.1002\/hbm.23183-BIB0010|hbm23183-cit-0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cell.2004.08.017","article-title":"Endocytosis by random initiation and stabilization of clathrin-coated pits","volume":"118","author":"Ehrlich","year":"2004","journal-title":"Cell"},{"key":"10.1002\/hbm.23183-BIB0011|hbm23183-cit-0011","doi-asserted-by":"crossref","first-page":"18180","DOI":"10.1523\/JNEUROSCI.4960-11.2011","article-title":"Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant","volume":"31","author":"Erk","year":"2011","journal-title":"J Neurosci"},{"key":"10.1002\/hbm.23183-BIB0012|hbm23183-cit-0012","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hbm.23183-BIB0013|hbm23183-cit-0013","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/mp.2010.123","article-title":"Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease","volume":"16","author":"Furney","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1002\/hbm.23183-BIB0014|hbm23183-cit-0014","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1002\/hbm.23183-BIB0015|hbm23183-cit-0015","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1002\/hbm.23183-BIB0016|hbm23183-cit-0016","doi-asserted-by":"crossref","DOI":"10.1038\/nature14101","article-title":"Common genetic variants influence human subcortical brain structures","author":"Hibar","year":"2015","journal-title":"Nature 520:224-229."},{"key":"10.1002\/hbm.23183-BIB0017|hbm23183-cit-0017","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jmri.10163","article-title":"Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia","volume":"16","author":"Hsu","year":"2002","journal-title":"J Magn Reson Imaging"},{"key":"10.1002\/hbm.23183-BIB0018|hbm23183-cit-0018","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"10.1002\/hbm.23183-BIB0019|hbm23183-cit-0019","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2014.4821","article-title":"Age, sex, and APOE epsilon4 effects on memory, brain structure, and beta-amyloid across the adult life span","author":"Jack","year":"2015","journal-title":"JAMA Neurol 72:511-519."},{"key":"10.1002\/hbm.23183-BIB0020|hbm23183-cit-0020","first-page":"487","volume-title":"Principal Component Analysis","author":"Jolliffe","year":"2002"},{"key":"10.1002\/hbm.23183-BIB0021|hbm23183-cit-0021","doi-asserted-by":"crossref","DOI":"10.1145\/2010324.1964974","article-title":"Blended intrinsic maps","volume":"30","author":"Kim","year":"2011","journal-title":"ACM Trans Graphics"},{"key":"10.1002\/hbm.23183-BIB0022|hbm23183-cit-0022","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"10.1002\/hbm.23183-BIB0023|hbm23183-cit-0023","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/archneurol.2010.292","article-title":"Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals","volume":"68","author":"Lee","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1002\/hbm.23183-BIB0024|hbm23183-cit-0024","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/npp.2014.63","article-title":"The impact of MIR137 on dorsolateral prefrontal-hippocampal functional connectivity in healthy subjects","volume":"39","author":"Liu","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hbm.23183-BIB0025|hbm23183-cit-0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1002\/hbm.23183-BIB0026|hbm23183-cit-0026","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.23644","article-title":"Multiple loci influencing hippocampal degeneration identified by genome scan","volume":"72","author":"Melville","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1002\/hbm.23183-BIB0027|hbm23183-cit-0027","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/hbm.20655","article-title":"Collaborative computational anatomy: An MRI morphometry study of the human brain via diffeomorphic metric mapping","volume":"30","author":"Miller","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1002\/hbm.23183-BIB0028|hbm23183-cit-0028","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.1016\/j.jalz.2013.11.001","article-title":"Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease","volume":"10","author":"Morgen","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1002\/hbm.23183-BIB0029|hbm23183-cit-0029","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.neuint.2006.11.002","article-title":"Amyloid-beta 1-42 induced endocytosis and clusterin\/apoJ protein accumulation in cultured human astrocytes","volume":"50","author":"Nuutinen","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1002\/hbm.23183-BIB0030|hbm23183-cit-0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","article-title":"Clusterin: A forgotten player in Alzheimer's disease","volume":"61","author":"Nuutinen","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1002\/hbm.23183-BIB0031|hbm23183-cit-0031","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hbm.20131","article-title":"N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies","volume":"25","author":"Owen","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"10.1002\/hbm.23183-BIB0032|hbm23183-cit-0032","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1002\/hbm.23183-BIB0033|hbm23183-cit-0033","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jalz.2010.03.013","article-title":"Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans","volume":"6","author":"Saykin","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.1002\/hbm.23183-BIB0034|hbm23183-cit-0034","doi-asserted-by":"crossref","unstructured":"Taubin G 1995 852 857","DOI":"10.1049\/cp:19950781"},{"key":"10.1002\/hbm.23183-BIB0035|hbm23183-cit-0035","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1198\/016214507000000815","article-title":"Detecting sparse signals in random fields, with an application to brain mapping","volume":"102","author":"Taylor","year":"2007","journal-title":"J Am Stat Assoc"},{"key":"10.1002\/hbm.23183-BIB0036|hbm23183-cit-0036","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0079-6123(08)61268-6","article-title":"Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease","volume":"83","author":"Hoesen","year":"1990","journal-title":"Prog Brain Res"},{"key":"10.1002\/hbm.23183-BIB0037|hbm23183-cit-0037","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1109\/TPAMI.2012.143","article-title":"Multi-atlas segmentation with joint label fusion","volume":"35","author":"Wang","year":"2013","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1002\/hbm.23183-BIB0038|hbm23183-cit-0038","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1097-0193(1999)8:2\/3<98::AID-HBM5>3.0.CO;2-F","article-title":"Detecting changes in nonisotropic images","volume":"8","author":"Worsley","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"10.1002\/hbm.23183-BIB0039|hbm23183-cit-0039","doi-asserted-by":"crossref","first-page":"e47406","DOI":"10.1371\/journal.pone.0047406","article-title":"CSF and brain structural imaging markers of the Alzheimer's pathological cascade","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/hbm.23183-BIB0040|hbm23183-cit-0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11263-015-0802-4","article-title":"Diffeomorphic metric landmark mapping using stationary velocity field parameterization","volume":"115","author":"Yang","year":"2015","journal-title":"Int J Comput Vis"},{"key":"10.1002\/hbm.23183-BIB0041|hbm23183-cit-0041","article-title":"Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults","author":"Zhang","year":"2014","journal-title":"Brain Struct Funct 220:1463-1475."},{"key":"10.1002\/hbm.23183-BIB0042|hbm23183-cit-0042","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2015.30","article-title":"Bridging integrator 1 (BIN1) genotype effects on working memory, hippocampal volume, and functional connectivity in young healthy individuals","author":"Zhang","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hbm.23183-BIB0043|hbm23183-cit-0043","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.csda.2005.09.010","article-title":"Automatic dimensionality selection from the scree plot via the use of profile likelihood","volume":"51","author":"Zhu","year":"2006","journal-title":"Comput Stat Data Anal"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23183","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hbm.23183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:14:45Z","timestamp":1748823285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23183"}},"subtitle":["PICALM-CLU Interaction on Hippocampus"],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"URL":"https:\/\/doi.org\/10.1002\/hbm.23183","archive":["Portico"],"relation":{},"ISSN":["1065-9471"],"issn-type":[{"value":"1065-9471","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}