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Tinnitus pathophysiology has been repeatedly shown to involve both auditory and non\u2010auditory brain structures, making network\u2010level studies of tinnitus critical. In this magnetic resonance imaging (MRI) study, two resting\u2010state functional connectivity (RSFC) approaches were used to better understand functional network disturbances in tinnitus. First, we demonstrated tinnitus\u2010related reductions in RSFC between specific brain regions and resting\u2010state networks (RSNs), defined by independent components analysis (ICA) and chosen for their overlap with structures known to be affected in tinnitus. Then, we restricted ICA to data from tinnitus patients, and identified one RSN not apparent in control data. This tinnitus RSN included auditory\u2013sensory regions like inferior colliculus and medial Heschl's gyrus, as well as classically non\u2010auditory regions like the mediodorsal nucleus of the thalamus, striatum, lateral prefrontal, and orbitofrontal cortex. Notably, patients' reported tinnitus loudness was positively correlated with RSFC between the mediodorsal nucleus and the tinnitus RSN, indicating that this network may underlie the auditory\u2013sensory experience of tinnitus. These data support the idea that tinnitus involves network dysfunction, and further stress the importance of communication between auditory\u2013sensory and fronto\u2010striatal circuits in tinnitus pathophysiology. <jats:italic>Hum Brain Mapp 37:2717\u20132735, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23204","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T07:06:48Z","timestamp":1461049608000},"page":"2717-2735","source":"Crossref","is-referenced-by-count":105,"title":["Intrinsic network activity in tinnitus investigated using functional MRI"],"prefix":"10.1002","volume":"37","author":[{"given":"Amber M.","family":"Leaver","sequence":"first","affiliation":[{"name":"Department of Neuroscience Georgetown University Medical Center Washington District of Columbia"},{"name":"Department of Neurology University of California Los Angeles Los 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