{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:20:32Z","timestamp":1791555632142,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Award 2015 of Tokyo Metropolitan Institute of Gerontology (to K.Ishibashi)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High plasma glucose (PG) levels can reduce fluorine\u201018\u2010labeled fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) uptake, especially in the Alzheimer's disease (AD)\u2010related regions. This fact is supported by studies showing that the resting\u2010state activity in diabetes can be altered in the default mode network (DMN)\u2010related regions, which considerably overlap with the AD\u2010related regions. In order to expand the current knowledge, we aimed to investigate the relationship between increasing PG levels and the regional cerebral metabolic rates for glucose (CMR<jats:sub>glc<\/jats:sub>) as a direct index of brain activity. We performed dynamic <jats:sup>18<\/jats:sup>F\u2010FDG positron emission tomography with arterial blood sampling once each in the fasting and glucose\u2010loading conditions on 12 young, healthy volunteers without cognitive impairment or insulin resistance. The absolute CMR<jats:sub>glc<\/jats:sub> values were calculated for the volume\u2010of\u2010interest (VOI) analysis, and normalized CMR<jats:sub>glc<\/jats:sub> maps were generated for the voxelwise analysis. The normalized measurement is known to have smaller intersubject variability than the absolute measurement, and may, thus, lead to greater statistical power. In VOI analysis, no regional difference in the CMR<jats:sub>glc<\/jats:sub> was found between the two conditions. In exploratory voxelwise analysis, however, significant clusters were identified in the precuneus, posterior cingulate, lateral parietotemporal, and medial prefrontal regions where the CMR<jats:sub>glc<\/jats:sub> decreased upon glucose loading (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, corrected). These regions include the representative components of both the DMN and AD pathology. Taken together with the previous knowledge on the relationships between the DMN, AD, and diabetes, it may be inferred that glucose loading induces hypometabolism in the AD\u2010related and DMN\u2010related regions. <jats:italic>Hum Brain Mapp 37:2823\u20132832, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23210","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:14:39Z","timestamp":1460312079000},"page":"2823-2832","source":"Crossref","is-referenced-by-count":33,"title":["Alteration of the regional cerebral glucose metabolism in healthy subjects by glucose loading"],"prefix":"10.1002","volume":"37","author":[{"given":"Kenji","family":"Ishibashi","sequence":"first","affiliation":[{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute of Gerontology Tokyo 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