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The degree of homotopic organization is known to vary across the cortex and homotopic connectivity is high in regions that share cross\u2010hemisphere structural connections or are activated by common input streams (e.g., the visual system). Damage to one or both regions, as well as damage to the connections between homotopic regions, could disrupt this functional organization. Here were introduce and test a computationally efficient technique, surface\u2010based homotopic interhermispheric connectivity (sHIC), that leverages surface\u2010based registration and processing techniques in an attempt to improve the spatial specificity and accuracy of cortical interhemispheric connectivity estimated with resting state functional connectivity. This technique is shown to be reliable both within and across subjects. sHIC is also characterized in a dataset of nearly 1000 subjects. We confirm previous results showing increased interhemispheric connectivity in primary sensory regions, and reveal a novel rostro\u2010caudal functionally defined network level pattern of sHIC across the brain. In addition, we demonstrate a structural\u2013functional relationship between sHIC and atrophy of the corpus callosum in multiple sclerosis (<jats:italic>r<\/jats:italic>\u2009=\u20090.2979, <jats:italic>p<\/jats:italic>\u2009=\u20090.0461). sHIC presents as a sensitive and reliable measure of cortical homotopy that may prove useful as a biomarker in neurologic disease. <jats:italic>Hum Brain Mapp 37:2849\u20132868, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23214","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T02:34:12Z","timestamp":1464143652000},"page":"2849-2868","source":"Crossref","is-referenced-by-count":14,"title":["A surface\u2010based technique for mapping homotopic interhemispheric connectivity: Development, characterization, and clinical application"],"prefix":"10.1002","volume":"37","author":[{"given":"Sean M.","family":"Tobyne","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Boratyn","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Augustana College Sioux Falls South Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas N.","family":"Greve","sequence":"additional","affiliation":[{"name":"Athinoula a. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mainero","sequence":"additional","affiliation":[{"name":"Athinoula a. 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