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In the case of major depressive disorder (MDD), recent studies regarding the RS\u2010fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self\u2010referential thoughts and ruminations has made the use of the resting\u2010state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS\u2010fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. <jats:italic>Hum Brain Mapp 37:2918\u20132930, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23215","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T11:47:52Z","timestamp":1461844072000},"page":"2918-2930","source":"Crossref","is-referenced-by-count":223,"title":["Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder"],"prefix":"10.1002","volume":"37","author":[{"given":"Murat","family":"Demirta\u015f","sequence":"first","affiliation":[{"name":"Department of Information and Communication Technologies Center for Brain and Cognition Universitat Pompeu Fabra Barcelona 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Barcelona Spain"},{"name":"Department of Clinical Sciences University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Ritter","sequence":"additional","affiliation":[{"name":"Max\u2010Planck Institute for Cognitive and Brain Sciences Leipzig Germany"},{"name":"Department of Neurology Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcis","family":"Cardoner","sequence":"additional","affiliation":[{"name":"Mental Health Department, Depression and Anxiety Program, Parc Taul\u00ed Sabadell Barcelona  Spain"},{"name":"Hospital Universitari Department of Psychiatry and Legal Medicine Universitat Aut\u00f2noma De Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Soriano\u2010Mas","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM)  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