{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:35:04Z","timestamp":1785321304675,"version":"3.55.0"},"reference-count":103,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["01GW0730"],"award-info":[{"award-number":["01GW0730"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Focus Program Translational Neuroscience of the Johannes-Gutenberg-University Mainz (PhD fellowship)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Response inhibition is the ability to suppress inadequate but prepotent or ongoing response tendencies. A fronto\u2010striatal network is involved in these processes. Between\u2010subject differences in the intra\u2010individual variability have been suggested to constitute a key to pathological processes underlying impulse control disorders. Single\u2010trial EEG\/fMRI analysis allows to increase sensitivity for inter\u2010individual differences by incorporating intra\u2010individual variability. Thirty\u2010eight healthy subjects performed a visual Go\/Nogo task during simultaneous EEG\/fMRI. Of 38 healthy subjects, 21 subjects reliably showed Nogo\u2010related ICs (Nogo\u2010IC\u2010positive) while 17 subjects (Nogo\u2010IC\u2010negative) did not. Comparing both groups revealed differences on various levels: On trait level, Nogo\u2010IC\u2010negative subjects scored higher on questionnaires regarding attention deficit\/hyperactivity disorder; on a behavioral level, they displayed slower response times (RT) and higher intra\u2010individual RT variability while both groups did not differ in their inhibitory performance. On the neurophysiological level, Nogo\u2010IC\u2010negative subjects showed a hyperactivation of left inferior frontal cortex\/insula and left putamen as well as significantly reduced P3 amplitudes. Thus, a data\u2010driven approach for IC classification and the resulting presence or absence of early Nogo\u2010specific ICs as criterion for group selection revealed group differences at behavioral and neurophysiological levels. This may indicate electrophysiological phenotypes characterized by inter\u2010individual variations of neural and behavioral correlates of impulse control. We demonstrated that the inter\u2010individual difference in an electrophysiological correlate of response inhibition is correlated with distinct, potentially compensatory neural activity. This may suggest the existence of electrophysiologically dissociable phenotypes of behavioral and neural motor response inhibition with the Nogo\u2010IC\u2010positive phenotype possibly providing protection against impulsivity\u2010related dysfunction. <jats:italic>Hum Brain Mapp 37:3114\u20133136, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/hbm.23230","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T05:55:24Z","timestamp":1462168524000},"page":"3114-3136","source":"Crossref","is-referenced-by-count":20,"title":["Data\u2010driven analysis of simultaneous EEG\/fMRI reveals neurophysiological phenotypes of impulse control"],"prefix":"10.1002","volume":"37","author":[{"given":"Lena","family":"Schm\u00fcser","sequence":"first","affiliation":[{"name":"Emotion Regulation and Impulse Control Group, Focus Program Translational Neuroscience, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University of Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Emotion Regulation and Impulse Control Group, Focus Program Translational Neuroscience, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University of Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arian","family":"Mobascher","sequence":"additional","affiliation":[{"name":"Emotion Regulation and Impulse Control Group, Focus Program Translational Neuroscience, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University of Mainz Mainz Germany"},{"name":"Department of Psychiatry and Psychotherapy St. Elisabeth Krankenhaus Lahnstein Lahnstein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Lieb","sequence":"additional","affiliation":[{"name":"Emotion Regulation and Impulse Control Group, Focus Program Translational Neuroscience, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University of Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Feige","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Albert Ludwigs University of Freiburg Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"T\u00fcscher","sequence":"additional","affiliation":[{"name":"Emotion Regulation and Impulse Control Group, Focus Program Translational Neuroscience, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University of Mainz Mainz Germany"},{"name":"Department of Psychiatry and Psychotherapy Albert Ludwigs University of Freiburg Medical Center Freiburg Germany"},{"name":"Department of Neurology Albert Ludwigs University of Freiburg Medical Center Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171200270X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0599"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.17.1.45.24053"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg067"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858407299288"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4682-05.2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-004-0488-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.121.1.65"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1026\/\/0012-1924.49.2.61"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.09.023"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00691-5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00024"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21368"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.08.016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.07.054"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn065"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.12.024"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2010.12.010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.11.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.06.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00703-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2004.04.005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900013754"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022155"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-6918(99)00008-6"},{"key":"e_1_2_6_32_1","volume-title":"Oscillatory Brain Activity and its Analysis on the Basis for MEG and EEG","author":"Feige B","year":"1999"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069674"},{"key":"e_1_2_6_34_1","volume-title":"User's Guide for the Structured Clinical Interview for DSM\u2010IV Personality Disorders (SCID\u2010II)","author":"First M","year":"1996"},{"key":"e_1_2_6_35_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u00ae Axis I Disorders (SCID\u2010I), Clinician Version, User's Guide","author":"First M","year":"1997"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.05.010"},{"key":"e_1_2_6_37_1","volume-title":"Borderline Personality Disorder Severity Index (BPDSI)","author":"Freese S","year":"1999"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00019-7"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460010306"},{"key":"e_1_2_6_40_1","volume-title":"Strukturiertes Klinisches Interview f\u00fcr DSM\u2010IV, Achse II: Pers\u00f6nlichkeitsst\u00f6rungen","author":"Fydrich T","year":"1997"},{"key":"e_1_2_6_41_1","volume-title":"Beck\u2010Depressions\u2010Inventar (BDI)","author":"Hautzinger M","year":"1995"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.03.014"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00077-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.039"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.08.001"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.02.034"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000304174"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5253-10.2011"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(92)90054-L"},{"key":"e_1_2_6_50_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1167\/3.7.4","article-title":"Timecourse of neural signatures of object recognition","volume":"3","author":"Johnson JS","year":"2003","journal-title":"J Vis"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.05.006"},{"key":"e_1_2_6_52_1","first-page":"41","article-title":"Deficits during voluntary selection in adult patients with ADHD: New insights from single\u2010trial coupling of simultaneous EEG\/fMRI","volume":"5","author":"Karch S","year":"2014","journal-title":"Neuropsychiatr Imaging Stimul"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.003"},{"key":"e_1_2_6_54_1","first-page":"3","article-title":"The ten\u2010twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology","volume":"52","author":"Klem GH","year":"1999","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.01.008"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00167.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0921-884X(96)95617-9"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096159"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03683.x"},{"key":"e_1_2_6_60_1","unstructured":"LawrenceMA(2015): ez: Easy analysis and visualization of factorial experiments. R package version 4.2\u20102. Available athttp:\/\/CRAN.R-project.org\/package=ez."},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1162\/089976699300016719"},{"key":"e_1_2_6_62_1","volume-title":"Manual zum MWT\u2010B","author":"Lehrl S","year":"1995"},{"key":"e_1_2_6_63_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0010-9452(08)70274-0","article-title":"Abnormal brain activity related to performance monitoring and error detection in children with ADHD","volume":"41","author":"Liotti M","year":"2005","journal-title":"Cortex J Devoted Study Nerv Syst Behav"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1006\/cogp.1999.0734"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20500"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.236"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21277"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0926-6410(94)90010-8"},{"key":"e_1_2_6_70_1","unstructured":"NeumannNU SchulteRM(1988): Bestimmung der Validit\u00e4t und Interrater\u2010Reliabilit\u00e4t der deutschen Fassung der Montgomery\u2010Asberg\u2010Depression\u2010Rating\u2010Skala(MADRS). Psycho sec. 14."},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-8986.2003.00128.x"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.04.011"},{"key":"e_1_2_6_75_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2014"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-002-1447-4"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2005.03.024"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2008.01.010"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0042-7"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2008.03.008"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.06.005"},{"key":"e_1_2_6_82_1","first-page":"175","article-title":"Data\u2010driven analysis of simultaneous EEG\/fMRI using an ICA approach","volume":"8","author":"Schm\u00fcser L","year":"2014","journal-title":"Front Neurosci"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.02.010"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.03.013"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.020"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-0994-y"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000175107"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2013.11.004"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.01.013"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.07.015"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033981"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg237"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.070"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0138-5"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200009)44:3<457::AID-MRM17>3.0.CO;2-R"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.01.022"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12374"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(00)00064-7"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390500212896"},{"key":"e_1_2_6_100_1","volume-title":"SKID: Strukturiertes klinisches Interview f\u00fcr DSM\u2010IV: Achse I und II","author":"Wittchen H\u2010U","year":"1997"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.06.023"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.058"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.032"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20261"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:09:18Z","timestamp":1696608558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":103,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/hbm.23230"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23230","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]}}}