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However, the literature on alterations in white matter (WM) volume and microstructure changes in both acutely underweight AN (acAN) and after recovery (recAN) is sparse and results are inconclusive. Here, T1\u2010weighted and diffusion\u2010weighted MRI data in a sizable sample of young and medication\u2010free acAN (<jats:italic>n<\/jats:italic>\u2009=\u200935), recAN (<jats:italic>n<\/jats:italic>\u2009=\u200932), and age\u2010matched female healthy controls (HC, <jats:italic>n<\/jats:italic>\u2009=\u200962) were obtained. For analysis, a well\u2010validated global probabilistic tractography reconstruction algorithm including rigorous motion correction implemented in FreeSurfer: TRACULA (TRActs Constrained by UnderLying Anatomy) were used. Additionally, a clustering algorithm and a multivariate pattern classification technique to WM metrics to predict group membership were applied. No group differences in either WM volume or WM microstructure were detected with standard analysis procedures either in acAN or recAN relative to HC after controlling for the number of performed statistical tests. These findings were not affected by age, IQ, or psychiatric symptoms. While cluster analysis was unsuccessful at discriminating between groups, multivariate pattern classification showed some ability to separate acAN from HC (but not recAN from HC). However, these results were not compatible with a straightforward hypothesis of impaired WM microstructure. The current findings suggest that WM integrity is largely preserved in non\u2010chronic AN. This finding stands in contrast to findings in GM, but may help to explain the relatively intact cognitive performance of young patients with AN and provide the basis for the fast recovery of GM structures. <jats:italic>Hum Brain Mapp 37:4069\u20134083, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23296","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T05:38:49Z","timestamp":1468301929000},"page":"4069-4083","source":"Crossref","is-referenced-by-count":33,"title":["Preserved white matter microstructure in young patients with anorexia nervosa?"],"prefix":"10.1002","volume":"37","author":[{"given":"Gerit","family":"Pfuhl","sequence":"first","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Department of Psychology, UiT the Arctic University of Norway &amp; Department of Psychology Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"King","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Geisler","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Roschinski","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Ritschel","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Seidel","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bernardoni","sequence":"additional","affiliation":[{"name":"Eating Disorders Research and Treatment Center at the Dept. of Child and Adolescent Psychiatry Faculty of Medicine, Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk K.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Center Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"White","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry &amp; 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