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However, the relationship between resting\u2010state functional connectivity (FC) reorganization in the sensorimotor network and motor disability in MS is not well understood. This study used resting\u2010state fMRI, T1\u2010weighted and T2\u2010weighted, and magnetization transfer (MT) imaging to investigate the relationship between abnormal FC in the sensorimotor network and upper limb motor disability in people with MS, as well as the impact of disease\u2010related structural abnormalities within this network. Specifically, the differences in FC of the left hemisphere hand motor region between MS participants with preserved (<jats:italic>n<\/jats:italic>\u2009=\u200917) and impaired (<jats:italic>n<\/jats:italic>\u2009=\u200926) right hand function, compared with healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200920) was investigated. Differences in brain atrophy and MT ratio measured at the global and regional levels were also investigated between the three groups. Motor <jats:italic>preserved<\/jats:italic> MS participants had stronger FC in structurally intact visual information processing regions relative to motor <jats:italic>impaired<\/jats:italic> MS participants. Motor <jats:italic>impaired<\/jats:italic> MS participants showed weaker FC in the sensorimotor and somatosensory association cortices and more severe structural damage throughout the brain compared with the other groups. Logistic regression analysis showed that regional MTR predicted motor disability beyond the impact of global atrophy whereas regional grey matter volume did not. More importantly, as the first multimodal analysis combining resting\u2010state fMRI, T1\u2010weighted, T2\u2010weighted and MTR images in MS, we demonstrate how a combination of structural and functional changes may contribute to motor impairment or preservation in MS. <jats:italic>Hum Brain Mapp 37:4262\u20134275, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23307","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T11:56:59Z","timestamp":1467806219000},"page":"4262-4275","source":"Crossref","is-referenced-by-count":27,"title":["Abnormal functional connectivity and cortical integrity influence dominant hand motor disability in multiple sclerosis: a multimodal analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Jidan","family":"Zhong","sequence":"first","affiliation":[{"name":"Research Institute of the McGill University Health Centre 2155 Guy Street, 5th Floor Montreal 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