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This skill is the isolated deficit in patients with writer's cramp (WC), a form of dystonia with maladaptive plasticity, acquired through intensive and repetitive motor practice. When a skill is highly trained, a motor program is created in the brain to execute the same movement kinematics regardless of the effector used for the task. The task\u2010 and effector\u2010specific symptoms in WC suggest that a problem particularly occurs in the brain when the writing motor program is carried out by the dominant hand. In this MRI study involving 12 WC patients (with symptoms only affecting the right dominant hand during writing) and 15 age matched unaffected controls we showed that: (1) the writing program recruited the same network regardless of the effector used to write in both groups; (2) dominant handwriting recruited a segregated parieto\u2010premotor network only in the control group; (3) local structural alteration of the premotor area, the motor component of this network, predicted functional connectivity deficits during dominant handwriting and symptom duration in the patient group. Dysfunctions and structural abnormalities of a segregated parieto\u2010premotor network in WC patients suggest that network specialization in focal brain areas is crucial for well\u2010learned motor skill.<jats:italic>Hum Brain Mapp 37:4363\u20134375, 2016<\/jats:italic>. \u00a9<jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23315","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T03:02:40Z","timestamp":1469674960000},"page":"4363-4375","source":"Crossref","is-referenced-by-count":59,"title":["Impairment of a parieto\u2010premotor network specialized for handwriting in writer's cramp"],"prefix":"10.1002","volume":"37","author":[{"given":"Cecile","family":"Gallea","sequence":"first","affiliation":[{"name":"Human Motor Control Section, Medical Neurology Branch NINDS, NIH 10 Center Drive, Bldg 10\/7D37 Bethesda Maryland 20892"},{"name":"Centre de Neuroimagerie de Recherche (CENIR), Inserm U 1127, CNRS UMR 7225, 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