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The neural responses and functional connectivity to a newly developed set of disorder\u2010related, ecologically valid scenes as compared with matched neutral visual scenes, using event\u2010related functional magnetic resonance imaging (fMRI) in 26 PD patients and 26 healthy controls (HC) were investigated. PD patients versus HC showed hyperactivation in an extended fear network comprising brainstem, insula, thalamus, anterior, and mid\u2010cingulate cortex and (dorso\u2010)medial prefrontal cortex for disorder\u2010related versus neutral scenes. Amygdala differences between groups failed significance. Subjective levels of anxiety significantly correlated with brainstem activation in PD patients. Analysis of functional connectivity by means of beta series correlation revealed no emotion\u2010specific alterations in connectivity in PD patients versus HC. 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