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In this report, a data\u2010driven, nonparameteric model to identify morphometric patterns separating HAND from MCI due to non\u2010HIV conditions in this older age group was proposed. This model enhanced the potential for group separation by combining a smaller, longitudinal data set containing HAND samples with a larger, public data set including MCI cases. Using cross\u2010validation, a linear model on healthy controls to harmonize the volumetric scores extracted from MRIs for demographic and acquisition differences between the two independent, disease\u2010specific data sets was trained. Next, patterns distinguishing HAND from MCI via a group sparsity constrained logistic classifier were identified. Unlike existing approaches, our classifier directly solved the underlying minimization problem by decoupling the minimization of the logistic regression function from enforcing the group sparsity constraint. The extracted patterns consisted of eight regions that distinguished HAND from MCI on a significant level while being indifferent to differences in demographics and acquisition between the two sets. Individually selecting regions through conventional morphometric group analysis resulted in a larger number of regions that were less accurate. In conclusion, simultaneously analyzing all brain regions and time points for disease specific patterns contributed to distinguishing with high accuracy HAND\u2010related impairment from cognitive impairment found in the HIV uninfected, MCI cohort. <jats:italic>Hum Brain Mapp 37:4523\u20134538, 2016<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23326","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T05:56:30Z","timestamp":1470290190000},"page":"4523-4538","source":"Crossref","is-referenced-by-count":21,"title":["Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-0719","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; 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