{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:09:11Z","timestamp":1790622551729,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Brain Mapping"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is growing evidence that sub\u2010structures of the brain scale allometrically to total brain size, that is, in a non\u2010proportional and non\u2010linear way. Here, scaling of different volumes of interest (VOI) to intra\u2010cranial volume (ICV) was examined. It was assessed whether scaling was allometric or isometric and whether scaling coefficients significantly differed from each other. We also tested to what extent allometric scaling of VOI was introduced by the automated segmentation technique. Furthermore, reproducibility of allometric scaling was studied different age groups and study populations. Study samples included samples of cognitively healthy adults from the community\u2010based Age Gene\/Environment Susceptibility\u2010Reykjavik Study (AGES\u2010Reykjavik Study) (<jats:italic>N<\/jats:italic>\u2009=\u20093,883), the Coronary Artery Risk Development in Young Adults Study (CARDIA) (<jats:italic>N<\/jats:italic> =709), and the Alzheimer's Disease Neuroimaging Initiative (ADNI) (<jats:italic>N<\/jats:italic>\u2009=\u2009180). Data encompassed participants with different age, ethnicity, risk factor profile, and ICV and VOI obtained with different automated MRI segmentation techniques. Our analysis showed that (1) allometric scaling is a trait of all parts of the brain, (2) scaling of neo\u2010cortical white matter, neo\u2010cortical gray matter, and deep gray matter structures including the cerebellum are significantly different from each other, and (3) allometric scaling of brain structures cannot solely be explained by age\u2010associated atrophy, sex, ethnicity, or a systematic bias from study\u2010specific segmentation algorithm, but appears to be a true feature of brain geometry. <jats:italic>Hum Brain Mapp 38:151\u2013164, 2017<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23351","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T02:17:37Z","timestamp":1472091457000},"page":"151-164","source":"Crossref","is-referenced-by-count":45,"title":["Allometric scaling of brain regions to intra\u2010cranial volume: An epidemiological MRI study"],"prefix":"10.1002","volume":"38","author":[{"given":"Laura W.","family":"de Jong","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010S\u00e9bastien","family":"Vidal","sequence":"additional","affiliation":[{"name":"Geriatrics Department AP\u2010HP, Broca Hospital Paris 75013 France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris V Paris EA 4468, 75006 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Zijdenbos","sequence":"additional","affiliation":[{"name":"Biospective Inc Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus","family":"Haight","sequence":"additional","affiliation":[{"name":"Intramural Research Program of the National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association Kopavogur Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association Kopavogur Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"van Buchem","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"Intramural Research Program of the National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.047"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.809688"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02192869"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21054"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.053"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199809000-00030"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk115"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(82)90285-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118718"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116529"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm244"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2007.10.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00356"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212030-00040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20187"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.4.701"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.01.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/4.4.331"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0987"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.024"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/13154"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00264"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.01.070"},{"key":"e_1_2_10_28_1","first-page":"620","article-title":"Measuring brain lesion progression with a supervised tissue classification system","volume":"11","author":"EI Zacharaki","year":"2008","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(94)90057-4"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.806283"}],"container-title":["Human Brain Mapping"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhbm.23351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hbm.23351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hbm.23351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:50:08Z","timestamp":1693896608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hbm.23351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/hbm.23351"],"URL":"https:\/\/doi.org\/10.1002\/hbm.23351","archive":["Portico"],"relation":{},"ISSN":["1065-9471","1097-0193"],"issn-type":[{"value":"1065-9471","type":"print"},{"value":"1097-0193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}