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Apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u025b4 allele imparts a high genetic risk of developing AD. Whether the <jats:italic>APOE<\/jats:italic> \u025b4 allele damages the brain when cognitive functions are still intact is important to understand, especially for possible early detection and intervention. This study aimed to examine the selective degeneration pattern associated with the <jats:italic>APOE<\/jats:italic> \u025b4 allele in the brains of cognitively normal elderly subjects. We enrolled 35 cognitively healthy \u025b4 carriers and 40 non\u2010carriers (53 to 81 years old) to evaluate group differences in cortical thickness and brain activation during a memory\u2010encoding task. We also assessed the functional connectivity of the brain regions with both structural and functional damages. The results from the neuropsychological tests showed that the performances of \u025b4 carriers and non\u2010carriers were comparable. Primarily, we found that the precuneus exhibited thinner cortical thickness and decreased deactivation during memory encoding. Furthermore, the connectivity analyses show that carriers exhibited damaged connectivity of the precuneus to several regions in the default mode network and the attention\/executive control network. Our study reveals the degeneration pattern of the \u025b4 allele, which could be used as a potential biomarker for early detection for possible interventions and treatments. <jats:italic>Hum Brain Mapp 38:271\u2013282, 2017<\/jats:italic>. \u00a9 <jats:bold>2016 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p>","DOI":"10.1002\/hbm.23359","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T04:06:01Z","timestamp":1473048361000},"page":"271-282","source":"Crossref","is-referenced-by-count":28,"title":["Precuneus degeneration in nondemented elderly individuals with <i>APOE<\/i> \u025b4: Evidence from structural and functional MRI analyses"],"prefix":"10.1002","volume":"38","author":[{"given":"Yaojing","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning &amp; IDG\/McGovern Institute for Brain Research Beijing Normal University Beijing People's Republic of China"},{"name":"BABRI Centre, Beijing 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